https://orcid.org/0000-0003-4611-8787
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Douglas C Miller, Re: Article by Machaalani et al. concerning dentate gyrus dysplasia, Journal of Neuropathology & Experimental Neurology, Volume 84, Issue 5, May 2025, Page 444, https://doi.org/10.1093/jnen/nlaf011
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To the Editor,
I read with interest the article in the January 2025 issue of the Journal by Machaalani, Rodriguez, and Vivekanandarajah describing the prevalence of hippocampal granule cell dispersion, and in particular bilamination, in a series of autopsy-derived brains across the entire age spectrum,1 especially in view of our own related study that was published in JNEN on-line in December and which appeared in print in the February 2025 issue.2 Viewing the study by Machaalani et al. in the context of our own data, the following points arise:
An important conclusion from both studies as well as most of the literature cited in each is that should a technique be developed to screen for dentate gyrus structural abnormalities, it will need to be recognized that such dysplasia is prevalent in some individuals at all ages. While our study and some others suggest that it is a risk factor for sudden unexpected death, not all affected individuals will suffer such death.1–3
