Meeting Cluster Issue: European Gamma Delta Community for 2022: 2nd International Workshop - Receiving and Translating Signals via the gamma delta TCR

A comprehensive analysis exploring the intricate correlation between γδ T cells and immune checkpoint receptors in melanoma is the focus of this study. Our findings provide a solid foundation for further exploration, suggesting the strategic combination of adoptive transfer or in vivo activation of γδ T cells with immune checkpoint inhibitor therapy as a compelling approach to enhance anti-tumor responses.

Innate- and adaptive-like γδ T cell subsets, their phenotypic profile and neighborhood composition can be characterized by high-dimensional imaging.

The generation and use of εTRuC γδ T cells is a new proof of concept for cancer immunotherapy.

Single-cell multimodal technologies are crucial for understanding the heterogeneity and specialized functions of γδ T cells, uncovering novel therapeutic opportunities in various diseases, including cancer.

We propose an analysis method, based on T cell receptor gene module scores, to identify γδ T cells from 5′-end single-cell RNA sequencing datasets.

Review of the origin and functions of γδ T cells in health and in chronic inflammation with the specific example of spondyloarthritis.