Volume 99, Issue 4, April 2016
Editorials
Editorial: Vγ9Vδ2 T cells: triple costimulation goes the distance
Discussion on the ex vivo generation of highly functional Vγ9Vδ2 T cells for adoptive immunotherapy.
Editorial: Lung macrophages high on cannabinoids: jamming PAMs and taming TAMs?
Discussion of cannabinoid receptors and the ECS in macrophage activation.
Spotlight on Leading Edge Research
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vγ9Vδ2 T cells in low levels of IL-2
Costimulatory signals from CD80, 4-1BB, and CD83L interactions are required for growth of human Vγ9Vδ2 T cells producing large amounts of cytokines.
Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors
Activation of CBs on HLMs reduces production of lymph/angiogenic factors; a possible novel strategy to modulate macrophage-assisted vascular remodeling.
Reviews
Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems
Review on techniques for inhibition of MPO activity and neutrophil response after injury to COPD and/or RA.
A matter of time: study of circadian clocks and their role in inflammation
Review of techniques used to study circadian rhythms and how the molecular clock influences immunity and inflammation.
Cell Development, Differentiation, … Trafficking
Lymph node trafficking of regulatory T cells is prerequisite for immune suppression
Abrogation of Treg-mediated immunosuppression by blockage of Treg LN trafficking suggests a hierarchy of the anatomic sites for immune regulation in Treg-based cell therapy.
Receptors, Signal Transduction, … Genes
Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration
The HDACi/PI3Ki combination suppresses BL cell proliferation and migration through alterations in PI3K signaling and HDAC function.
Inflammation, Extracellular Mediators, … Effector Molecules
Basophils are dispensable for the recovery of gross locomotion after spinal cord hemisection injury
MCs are essential for functional repair after CNS trauma, where basophils do not affect gross locomotor recovery after SCI.
The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation
Functional and molecular effects of tryptophan metabolite PA on CD4+ T cell activation.
Serum amyloid A inhibits osteoclast differentiation to maintain macrophage function
Host Defense … Pathophysiology
Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection
Tregs generated in BCG-vaccinated mice focus on dampening immunity rather than controlling immunopathology.
Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages
Pathogenesis of TPE is marked by functional impairment of AMΦs, alternative activation of lung macrophages, and upregulation of anti-apoptotic genes by Eos.
Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury
MPLA-induced G-CSF facilitates early expansion, mobilization, and recruitment of neutrophils to infection sites after burn, allowing for robust immune response to infection.
