Volume 98, Issue 5, November 2015
Editorials
Editorial: IFN-β immunomodulation: a tail of two STATS
Discussion of how IFNβ modulates immune responses mediated through STATs-1 and -2.
Editorial: Tweaking T cell receptor signaling thresholds through DAG: the role of diacylglycerol kinase ζ in T cell responses to TGF-β
Discussion on the influence of diacyglycerol kinase ζ on TGFβ sensitivity in the context of T cell activation and immune tolerance.
Spotlight on Leading Edge Research
Differential effects of IFN-β on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells
In vivo and in vitro inhibition of IL-12, IL-23, and IL-10 stimulation by IFNβ.
TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β
Enhancing TCR signal strength can attenuate TGFβ-mediated transcriptional changes and functions in CD8+ T cells, independent of changes to canonical TGFβ signaling.
Reviews
Parainflammation, chronic inflammation, and age-related macular degeneration
Review of how the protective para-inflammatory response is dysregulated, leading age-related macular degeneration.
Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease
Review of mechanisms leading to pulmonary manifestations in IBD patients, including dysfunctional immune cell homing, microbial dysbiosis, and systemic inflammation.
Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications
Review of how lipid rafts affect Fas/CD95 apoptotic signaling in hematologic cancer and normal cells, and their therapeutic prospects in cancer and autoimmune diseases.
Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution
Review of how Perforin-2/Mpeg1 is highly conserved from Porifera to modern vertebrates, assisting the innate immune system in destruction of foreign organisms.
Primary Research
An increased expression of PI-PLCβ1 is associated with myeloid differentiation and a longer response to azacitidine in myelodysplastic syndromes
Nuclear PI-PLCβ1 expression is differentially modulated in low- and high-risk MDS patients responding to azacitidine, contributing to the activation of myeloid differentiation.
Cell Development, Differentiation, … Trafficking
Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells
Notch promotes thymic development and cyotokine production of invariant NKT cells in the periphery.
Inflammation, Extracellular Mediators, … Effector Molecules
Phospholipid scramblase 1 is required for β2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation
Endothelial cell expression of phospholipid scramblase 1 is required for β2-glycoprotein I binding and subsequent inflammation.
Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model
Differences in inflammatory response between male and female C57BL6 mice.
Impaired innate immune response of leukocytes from ascitic fluid of patients with spontaneous bacterial peritonitis
Phenotype and functionality of human macrophages in ascites from cirrhotic patients and how antibiotic treatment changed their characteristics.
Immunomodulation in host-protective immune response against murine tuberculosis through regulation of the T regulatory cell function
STAT4 is involved in MIP-mediated host protection against experimental tuberculosis through down-regulation of Treg cell function.
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis
Lipid mediator release depends on the hydrolysis of triglyceride-rich lipid droplets mediated by ATGL, a potent regulator of inflammatory diseases.
Host Defense … Pathophysiology
Tuberculous pleurisy drives marked effector responses of γδ, CD4+, and CD8+ T cell subpopulations in humans
Over-reactive effector responses of γδ T and αβ T cells, and their interrelation with Foxp3+ Treg in pleural and other compartments.
A Cys-Gly-Cys triad in the dehydrogenase region of Nox2 plays a key role in the interaction with p67phox
Identification of the binding site for p67phox in the dehydrogenase region of Nox2.
