Volume 94, Issue 6, Dec 2013

Discussion on IL-4 pleotropic effects on CD8+ T cells and its effects on multiple types of effectors, including IL-10-producing immune suppressors.

Discussion of AMPK in both antigen presenting cells, and T cell responses.

IL-4 induced IL-10-producing CD8+ T cells possess suppressive function both in vitro and in vivo.

AMPK attenuates CD40-mediated inflammatory activity in myeloid APC; its activity in both APC and T cells contributes to T cell functional polarization.

Basic Research Review for Clinicians: Mechanisms underlying the anti-tumor and anti-CMV functions of NK cells, and γδ T cells, as the preclinical basis of high risk leukemia treatment, focusing on hematopoietic stem cell transplantation.

Clinical Review for Basic Researchers: The available clinical evidence supporting the role of NK cells, and γδ T lymphocytes, in killing tumor cells in haematological malignancies, focusing on strategies optimizing these cells in clinical practice.

Review on how IL-27 balances inflammation during infectious and autoimmune diseases.

Review on the role of cellular stress proteins in innate immune signaling responses during infection and inflammation.

Review on how the Epstein Barr virus engages a comprehensive set of innate leukocytes to initiate protective innate and adaptive immunity.

Review of evidence that ectopic lymphoid neogenesis, while playing a fundamental role in regulating anti-viral immunity, also favors breach of self-immunological tolerance and development of autoimmunity.

Review of current immunotherapeutic approaches in the treatment of non-small cell lung cancer.

Molecular mechanisms by which the isoprenoid derivative iPA synergizes with IL-2, for the expansion and cytotoxicity of human primary NK cells.

In Omenn syndrome, altered dendritic cell distribution and impaired migration represent an additional level of immune dysregulation, contributing to the pathogenesis of autoimmunity.

Spirochetal RNA is the ligand for human TLR8; activation of this receptor occurs within the phagosome.

GRK3−/− mice exhibit impaired CXCL12/CXCR4 responses, myelokathexis and hypogammaglobulinemia, as in WHIM syndrome, and are protected in inflammatory arthritis models by altered granulocyte trafficking.

Bile acids suppress pro-inflammatory cytokine production resulting in a switch of the IL-10/IL-12 ratio, a hallmark of regulatory or anti-inflammatory macrophages.

Essential role for the GTPase, Rab27a, in eosinophil exocytosis using in vitro and in vivo degranulation assays.

E. faecalis lipoteichoic acid induces chemokine expression via TLR2/CD14/MyD88 and PAFR/JAK/STAT1 signaling pathways, without induction of IFN-β in murine macrophages.

Glucocorticoids lack the capacity to further augment neutrophil survival, in severe hypoxia.

TSP-1-positive DCs promote the Th-17 immune response in the eye, after exposure to desiccating surface stress.

IL-17A induced granulopoiesis and megakaryopoiesis depends on the presence of TPO/c-mpl.

Adenosine signaling augments IL-10-induced STAT-3 dependent gene expression in macrophages, suggesting its role in M2c polarization.

CXCL6 is expressed in the lung; its blockade reduces lung inflammation and collagen deposition in a mouse model of bleomycin-induced pulmonary fibrosis.

Kupffer cells consist of resident CD32/CD68+ cells and recruited CD11b+ cells, which engage in bactericidal and antitumor immunity.

Evidence for a role of plasmacytoid dendritic cells and Th17 mediated responses in human cutaneous acute GVHD.