Volume 117, Issue 5, May 2025
News and Views
Natural antibodies as frontline helpers in bacterial clearance
Mechanism of encapsulated bacteria recognition and capture by Kupffer cells.
Reviews
Hematopoietic stem and progenitor cells fine-tuning the “sweet” of trained immunity
Hematopoietic stem and progenitor cells fine tune the intensity and persistence of immune responses through endogenous and exogenous activators, endowing innate immune cells with memory capabilities. This enables the immune system to develop a holistic adaptive strategy against infections and inflammation, originating from the hematopoietic niche.
Anti-tumor necrosis factor therapy in the treatment of systemic autoinflammatory diseases: the responses of innate immune cells
This review explores the clinical relevance of anti-tumor necrosis factor therapy in systemic autoinflammatory diseases, focusing on its impact on innate immune cells and examining how tumor necrosis factor, through its receptors or reverse signaling, regulates various innate immune cell activities implicated in systemic autoinflammatory disease pathogenesis.
Research Articles
Utility of the neutrophil-to-lymphocyte ratio and the ratio of neutrophil-to-lymphocyte ratio after and before adverse events for differential diagnosis of immune-related adverse events and bacterial infections in cancer patients treated with PD-(L)1 inhibitors
The NLR along with the post-NLR/pre-NLR ratio in distinguishing between irAEs and bacterial infections.
E26 transformation-specific-1 controls asthma development by regulating the CD4+ Th2/Th17 immune response involved transcription factors in active genomic transcriptional regions
Ets1 plays a regulatory role in asthma pathogenesis by suppressing Th2 and Th17 cells and their cytokines production. This modulation helps to maintain the balance between Th1/Th2 and Th17/Treg cells, thereby mitigating the severity of asthma.
Article
Distinct roles of PGE2 signaling via EP2 and EP4 in circulating pDCs: Implications for immune modulation in the tumor microenvironment
PGE2 signaling via EP2 and EP4 steers pDCs toward a suppressive state and impacts the phenotype of tumor-exposed pDCs.
Brief Report
Afucosylated broadly neutralizing antibodies targeting the HIV envelope elicit enhanced NK-cell–mediated cytotoxicity against HIV-infected CD4+ T-cell and macrophage targets
Afucosylated anti-HIV antibodies enhance antibody-dependent cellular cytotoxicity responses of natural killer cells against HIV-infected cells.
