Volume 100, Issue 1, Jul 2016

Discussion of the relationship between human T_reg potency and inhibition of TCR signaling in T_eff cells.

Discussion on the exogenous and endogenous regulatory pathways, which control phagosomal reduction.

Potency of T_reg suppressive function determines intracellular signaling, immune responsiveness, and later susceptibility of T_eff to immune suppression.

Cytosolic reductive pathways act with the uptake of Cys from the extracellular space to maintain reductive capacity of the phagosome.

Review of the TRIF adaptor protein’s role in TLR signaling pathways, and its involvement in disease processes.

Review on parallels that leprosy immune T cell response brings to cancer immunosurveillance, immunoediting, and immunotherapy.

Review of the range of swarm-like neutrophil tissue dynamics, and how multiple chemoattractants control sequential steps of neutrophil swarming in different tissue contexts.

Review of connections between T1D genetic susceptibility and alterations of DC-mediated tolerance, and potential immunotherapy for autoimmunity.

Review on MNT-comprised intercellular networks in immune cell function and dysfunction, with a focus on myeloid lineage APCs.

Redirecting macrophage polarization with PGE₂ inhibits development of allergic lung inflammation, and independent of macrophage origin, increasing its potential for therapy.

Deletion of LTβR in the myeloid compartment results in an altered cellular immune response to mucosal viral infection, without a defect in viral clearance.

RA promotes Th1 and Th17 responses by modulating CD103⁺ DCs, in the presence of inflammation.

EMH in the spleen increases with age, in a TNF-dependent manner.

TGM activity in human M2 macrophages requires the presence of a functional PLA2G5, generating PGE2.

MyoIIA regulates leukemia cell engraftment and dissemination into the brain, by promoting TEM of Bcr-Abl⁺ ALL cells.

LPS upregulates RNF144B in human macrophages for optimal IL-1β expression and priming of inflammasome responses, but is not LPS-inducible in mouse macrophages.

SFKs are required for CSF-1R signaling to motility and invasion, with different expression profiles in human and mouse macrophages.

TLT2 expression is conserved between mouse and human, and increased on leukocytes, in response to microbial products.

C-type lectin receptor Mincle involvement on the modulation of TLR4 inflammatory responses.

SPHK1/2 regulation of efferocytosis in macrophages offers a novel therapeutic approach for COPD.

Diminished IFN-γ in the lungs of 21- day-young (toddler) mice throughout infection corresponds to intrinsic rather than extrinsic CD4 T cell limitations in IFN-γ transcription, indicating a limited CD4 T cell response in toddler age.

Ruxolitinib blockade of STAT3 phosphorylation in IL-6/23- stimulated neutrophils, inhibits RORγt translocation, IL-1- induced production of ROS, MMP9, and elastase activity, and modulates Aspergillus fumigatus corneal infections.

In advanced HIV-1 disease, 24 weeks of ART-mediated recovery results in reversal of activated cell-specific monocyte subsets, with minimal recovery of soluble makers of tissue-associated myeloid activation.

A tool-kit of adapted and optimized methods allowing for detailed functional examination of human MAIT cells responding to bacterial antigen.

A microfluidic assay enables precise characterization of neutrophil migration in the native blood environment, independent of the donor species, and at single cell resolution.