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Adoption of a novel medium for the industrial (3000 L) production of Serendipita indica employing a nutrient limitation strategy using insoluble carbon and phosphate sources
Jubair Al Rashid and others
Journal of Industrial Microbiology and Biotechnology, Volume 52, 2025, kuaf009, https://doi.org/10.1093/jimb/kuaf009
The use of the endophytic fungus Serendipita indica has rapidly increased due to its wide range of host species, ability to foster plant-growth, and ability to confer tolerance to a number of stresses. However, its industrial-scale production is still in its infancy due to its low-biomass yield and ...
Exploration of Alternative Microfiltration Modalities for the Harvest and Clarification of Diverse Recombinant Proteins from High-Density E. coli Culture and Lysate using Hollow Fiber, Flat Sheet Cassette, and Vibro Membrane Filtration Technologies
Jennifer Reid and others
Journal of Industrial Microbiology and Biotechnology, kuaf008, https://doi.org/10.1093/jimb/kuaf008
One sentence summary: High-density E. coli microfiltration and lysate clarification was tested for three diverse recombinant proteins, where hollow fiber and vibro membrane filtration outperformed flat sheet cassette in terms of process time, suspended solid loading, and target protein recovery.
An overview of key industrial product citric acid production by Aspergillus niger and its application
Ambreen Latif and others
Journal of Industrial Microbiology and Biotechnology, Volume 52, 2025, kuaf007, https://doi.org/10.1093/jimb/kuaf007
Citric acid possesses high economic value and is considered as the world’s largest consumed organic acid in numerous industries. Citric acid applications range from food to beverage industries, pharmaceuticals, cosmetics, and the environment. It is mostly produced by microbial fermentation, but ...
Finding of the positive impact of glucose on the production of indican over indigo in engineered Escherichia coli
Hyun Jin Kim and others
Journal of Industrial Microbiology and Biotechnology, Volume 52, 2025, kuae048, https://doi.org/10.1093/jimb/kuae048
Indigo is a plant-based natural blue dye that can be produced via chemical synthesis and biological pathways. However, the toxic reduction processes and intracellular production of indigo through microbial metabolism are often limited by insolubility of indigo and complex downstream processing, ...
Metagenomic mining unveils a novel GH130 enzyme with exclusive xylanase activity over a wide temperature and pH ranges
Amr A Hemeda and others
Journal of Industrial Microbiology and Biotechnology, Volume 52, 2025, kuaf006, https://doi.org/10.1093/jimb/kuaf006
The equine gut harbors a diverse microbial community and represents a rich source of carbohydrate-active enzymes (CAZymes). To identify and characterize potentially novel CAZymes from a horse's hindgut metagenome, shotgun metagenomic sequencing was performed on DNA extracted from a stool sample of ...

Most cited

Antifungal activity and mechanism of action of natural product derivates as potential environmental disinfectants
Norma Patricia Silva-Beltrán and others
Journal of Industrial Microbiology and Biotechnology, Volume 50, Issue 1, 2023, kuad036, https://doi.org/10.1093/jimb/kuad036
There have been a considerable number of antifungal studies that evaluated natural products (NPs), such as medicinal plants and their secondary metabolites, (phenolic compounds, alkaloids), essential oils, and propolis extracts. These studies have investigated natural antifungal substances for use as food preservatives, ...
Optimizing the strain engineering process for industrial-scale production of bio-based molecules
Eric Abbate and others
Journal of Industrial Microbiology and Biotechnology, Volume 50, Issue 1, 2023, kuad025, https://doi.org/10.1093/jimb/kuad025
Biomanufacturing could contribute as much as ${\$}$ 30 trillion to the global economy by 2030. However, the success of the growing bioeconomy depends on our ability to manufacture high-performing strains in a time- and cost-effective manner. The Design–Build–Test–Learn (DBTL) framework has proven to be an effective strain ...
Small molecule inducers of actinobacteria natural product biosynthesis
Amir Y Alwali and Elizabeth I Parkinson
Journal of Industrial Microbiology and Biotechnology, Volume 50, Issue 1, 2023, kuad019, https://doi.org/10.1093/jimb/kuad019
Actinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural ...
Bacterial natural product discovery by heterologous expression
Adjo E Kadjo and Alessandra S Eustáquio
Journal of Industrial Microbiology and Biotechnology, Volume 50, Issue 1, 2023, kuad044, https://doi.org/10.1093/jimb/kuad044
Natural products have found important applications in the pharmaceutical and agricultural sectors. In bacteria, the genes that encode the biosynthesis of natural products are often colocalized in the genome, forming biosynthetic gene clusters. It has been predicted that only 3% of natural products encoded in bacterial ...
CRISPR-aided genome engineering for secondary metabolite biosynthesis in Streptomyces
Yongjae Lee and others
Journal of Industrial Microbiology and Biotechnology, Volume 51, 2024, kuae009, https://doi.org/10.1093/jimb/kuae009
The demand for discovering novel microbial secondary metabolites is growing to address the limitations in bioactivities such as antibacterial, antifungal, anticancer, anthelmintic, and immunosuppressive functions. Among microbes, the genus Streptomyces holds particular significance for secondary metabolite discovery. Each ...

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