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Anil K. Chaturvedi, Barry I. Graubard, Robert K. L. Pickard, Weihong Xiao, Maura L. Gillison, High-Risk Oral Human Papillomavirus Load in the US Population, National Health and Nutrition Examination Survey 2009–2010, The Journal of Infectious Diseases, Volume 210, Issue 3, 1 August 2014, Pages 441–447, https://doi.org/10.1093/infdis/jiu116
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Abstract
We investigated the association of demographic and behavioral factors with oral human papillomavirus (HPV) load for 18 high-risk types among 211 individuals with prevalent high-risk HPV within the National Health and Nutrition Examination Survey 2009–2010. Factors independently associated with HPV load above the median included older age (odds ratio, 1.04 per year increase [95% confidence interval, 1.01–1.07]; P = .004) and intensity of current smoking (P for trend <.001). A marginally greater percentage of men than women had an HPV load above the median (55.7% vs 32.8%; P = .069), and HPV load increased marginally with increasing alcohol use (P for trend = .062). In conclusion, older age and current smoking are associated with a high oral load of high-risk HPV types among individuals with a prevalent infection.