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Romel D. Mackelprang, Abigail W. Bigham, Connie Celum, Guy de Bruyn, Kristin Beima-Sofie, Grace John-Stewart, Allan Ronald, Nelly R. Mugo, Kati J. Buckingham, Michael J. Bamshad, James I. Mullins, M. Juliana McElrath, Jairam R. Lingappa, Toll-like Receptor Polymorphism Associations With HIV-1 Outcomes Among Sub-Saharan Africans, The Journal of Infectious Diseases, Volume 209, Issue 10, 15 May 2014, Pages 1623–1627, https://doi.org/10.1093/infdis/jit807
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Abstract
Objective. We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples.
Methods. Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls.
Results. TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression.
Conclusions. TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.