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Dagmar Kiesslich, Myuki Alfaia Crispim, Carlos Santos, Fernando de Lima Ferreira, Nelson Abrahim Fraiji, Shirley Vasconcelos Komninakis, Ricardo Sobhie Diaz, Influence of Hepatitis B Virus (HBV) Genotype on the Clinical Course of Disease in Patients Coinfected with HBV and Hepatitis Delta Virus, The Journal of Infectious Diseases, Volume 199, Issue 11, 1 June 2009, Pages 1608–1611, https://doi.org/10.1086/598955
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Abstract
ObjectiveWe evaluated the influence of hepatitis B virus (HBV) genotype on the course of disease in patients coinfected with HBV and hepatitis delta virus (HDV)
MethodsWe evaluated HBV genotypes in 190 patients, 140 of whom had chronic HBV monoinfection and 50 of whom had chronic HBV-HDV coinfection. Real-time polymerase chain reactions for the amplification of HBV DNA and HDV RNA were developed, and we compared the patient groups with respect to HBV genotype, viral load, alanine aminotransferase (ALT) and bilirubin levels, and disease severity
ResultsCoinfected patients had higher ALT and bilirubin levels as well as a higher prevalence of liver cirrhosis and liver carcinoma. ALT levels were higher among individuals coinfected with HDV and HBV genotype F than among individuals infected only with HBV genotype F. Among HDV-HBV–coinfected patients, HDV load was lower among those infected with HBV genotype A than among those infected with HBV genotype D or genotype F
ConclusionLiver inflammation and HDV load are influenced by HBV genotype in individuals coinfected with HBV and HDV