-
Views
-
Cite
Cite
Ignatius W. Fong, Brian Chiu, Esther Viira, William Tucker, Heidi Wood, Rosanna W. Peeling, Chlamydial Heat-Shock Protein–60 Antibody and Correlation with Chlamydia pneumoniae in Atherosclerotic Plaques, The Journal of Infectious Diseases, Volume 186, Issue 10, 15 November 2002, Pages 1469–1473, https://doi.org/10.1086/344730
- Share Icon Share
Abstract
A study was performed to determine whether serum antibody to Chlamydial heat-shock protein–60 (CHSP-60) and C-reactive protein (CRP) were associated with the presence of Chlamydia pneumoniae in atheromatous plaques in 75 patients. The mean (±SD) ELISA optical density (OD) of anti–CHSP-60 was 0.19±0.15 in 54 patients with detectable C. pneumoniae antigen, versus an OD of 0.11±0.08 in 21 patients without detectable C. pneumoniae I antigen (P=.008). Higher anti–CHSP-60 at an OD ⩾0.12 was present in 38 (70.4%) of patients with detectable C. pneumoniae in atheromas, compared with 5 (23.8%) of patients without C. pneumoniae antigen (P<.001; 2-tailed test). The mean CRP concentration was 7.4±10.3 mg/L in patients with detectable C. pneumoniae antigen, versus 5.7±6.1 mg/L in those without (P=.556). Immune response to CHSP-60 may play a role in atherogenesis, but CRP serum levels does not appear to be related to C. pneumoniae infection