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Jianhui Zhu, Arshed A. Quyyumi, James E. Norman, Rene Costello, Gyorgy Csako, Stephen E. Epstein, The Possible Role of Hepatitis A Virus in the Pathogenesis of Atherosclerosis, The Journal of Infectious Diseases, Volume 182, Issue 6, December 2000, Pages 1583–1587, https://doi.org/10.1086/317613
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Abstract
The possible association between hepatitis A virus (HAV) infection and coronary artery disease (CAD) was studied. Blood from 391 patients undergoing coronary angiography was tested for serum IgG antibodies to HAV and C-reactive protein (CRP). Of the 391 patients, 205 (52%) had anti-HAV IgG antibodies. CAD prevalence was 74% in HAV-seropositive and 52% in HAV-seronegative patients (P < .0001); significance persisted after adjustment for either traditional CAD risk factors or for risk factors plus other infectious agents (cytomegalovirus, Chlamydia pneumoniae, Helicobacterpylori, and herpes simplex virus). In addition, CRP levels were significantly higher in HAV-seropositive than in HAV-seronegative patients (P = .013) in both univariate and multivariate analyses. Logistic regression analysis demonstrated that HAV seropositivity is an independent predictor of risk for CAD and elevated CRP levels. HAV infection is therefore associated with CAD, which raises the possibility that this virus may play a causal role in atherogenesis.
- atherosclerosis
- coronary angiography
- coronary arteriosclerosis
- chlamydophila pneumoniae
- simplexvirus
- infections
- c-reactive protein
- cytomegalovirus
- hepatitis a virus
- viruses
- infectious agent
- igg antibody
- atherogenesis
- hepatitis a virus antibodies
- coronary heart disease risk
- c-reactive protein, increased