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Jennifer Webster-Cyriaque, Rachel H. Edwards, Evelyn B. Quinlivan, Lauren Patton, David Wohl, Nancy Raab-Traub, Epstein-Barr Virus and Human Herpesvirus 8 Prevalence in Human Immunodeficiency Virus-Associated Oral Mucosal Lesions, The Journal of Infectious Diseases, Volume 175, Issue 6, June 1997, Pages 1324–1332, https://doi.org/10.1086/516463
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Abstract
The prevalence of Epstein-Barr virus (EBV) and the recently identified Kaposi's sarcoma (KS)-associated herpesvirus (also designated human herpesvirus 8 [HHV-8]) was determined in oral lesions and oral neoplasms common to persons with human immunodeficiency virus (HIV) infection. Oral lesions were examined by polymerase chain reaction (PCR) for EBV and HHV-8 DNA and by Southern blot analysis for EBV clonality. EBV was detected by Southern blot in hairy leukoplakia lesions, in a subset of AIDS-related lymphomas, and in saliva from HIV-positive persons but not in pseudohairy leukoplakia lesions, oral aphthous ulcers, or oral KS lesions. EBV was detected, however, by PCR in most of the lesions, while HHV-8 was detected only in oral KSs. The absence of HHV-8 DNA in both the EBV-associated hairy leukoplakia lesions and in the EBV-associated AIDS-related lymphomas strengthens the etiologic relationship of EBV to these pathologies and the etiologic role of HHV-8 in KS.
- polymerase chain reaction
- hiv
- kearns-sayre syndrome
- herpesviridae
- herpesvirus 4, human
- simplexvirus
- lymphoma, aids-related
- hairy leukoplakia
- southern blot assay
- dna
- human herpesvirus 8
- hiv seropositivity
- immunologic deficiency syndromes
- leukoplakia
- oral mucous membrane
- mouth neoplasms
- oral ulcer
- saliva
- kaposi sarcoma
- aphthous stomatitis
- infections
- viruses
- clonality (genetic analysis)