-
Views
-
Cite
Cite
Nathalie Boyer, Patrick Marcellin, Claude Degott, Francoise Degos, Adrien Gérard Saimot, Serge Erlinger, Jean Pierre Benhamou, Recombinant Interferon-α for Chronic Hepatitis C in Patients Positive for Antibody to Human Immunodeficiency Virus, The Journal of Infectious Diseases, Volume 165, Issue 4, April 1992, Pages 723–726, https://doi.org/10.1093/infdis/165.4.723
- Share Icon Share
Abstract
To assess the response to and tolerance of recombinant interferon-α administration in patients with chronic hepatitis C and human immunodeficiency virus (HIV) infection, 12 patients with chronic hepatitis C and HIV infection were given interferon-α, 1, 3, or 5 million units thrice weekly, for 4 or 6 months. Four patients had a complete response (normal serum alanine aminotransferase activity [ALT]), 3 had a near-complete response (serum ALT less than one-and-onehalf times the upper limit of normal), and 5 had no response at the end of administration. Histologic examination of liver showed an improvement in 1 patient with complete response and no improvement in another patient with no response. In patients with chronic hepatitis C with HIV infection, the response to and tolerance of recombinant interferon-a were not different from those usually observed in patients with chronic hepatitis C infection without HIV infection.