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Margherita T. Cantorna, Edward Balish, Acquired Immunity to Systemic Candidiasis in Immunodeficient Mice, The Journal of Infectious Diseases, Volume 164, Issue 5, November 1991, Pages 936–943, https://doi.org/10.1093/infdis/164.5.936
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Abstract
Twenty-seven percent of beige-athymic (bg/bg nu/nu) mice died of systemic candidiasis 7–20 weeks after gastrointestinal tract colonization with Candida albicans. Conversely, beige-euthymic (bg/bg nu/+) mice colonized with C. albicans for a similar time period did not die or develop systemic candidiasis. C. albicans-colonized bg/bg nu/+ mice, but not bglbg nuinu mice, developed C. albicans-specific T cell-dependent antibody- and cell-mediated immune responses, indicating that T cell-dependent responses might explain the acquired resistance of bg/bg nu/+ mice to systemic candidiasis. Colonization with C. albicans enhanced the resistance of T cellcompetent bglbg nui-t- mice, but not bg/bg nu/nu mice, to systemic candidiasis. T cell-mediated immunity activated after mucosal colonization with C. albicans plays an important role in resistance to systemic candidiasis.