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A. Nansen, J. Pravsgaard Christensen, O. Marker, A. Randrup Thomsen, Sensitization to Lipopolysaccharide in Mice with Asymptomatic Viral Infection: Role of T Cell-Dependent Production of Interferon-γ, The Journal of Infectious Diseases, Volume 176, Issue 1, July 1997, Pages 151–157, https://doi.org/10.1086/514017
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Abstract
The interplay between viral infection and lipopolysaccharide (LPS) was studied. Infection with a noncytopathogenic virus, lymphocytic choriomeningitis virus (LCMV), was found to sensitize mice to low doses of LPS. In vivo, this hypersensitivity correlated with hyperproduction of tumor necrosis factor-α (TNF-α), and in vitro, LPS-stimulated splenic adherent cells produced increased amounts of TNF-α. Hyperproduction of TNF-α was temporally correlated with virus-induced production of interferon-γ (IFN-γ); only marginally increased IFN-γ and TNF-α production was observed in LCMV-infected, T cell-deficient mice and in mice infected with vesicular stomatitis virus, a virus that induces much less T cell activation than does LCMV. Finally, LCMV infection was much less efficient in priming IFN-γ knockout mice for hyperproduction of TNF-α. These findings indicate that clinically silent viral infections may induce hypersensitivity to LPS through T cell activation and subsequent production of IFN-γ; this sensitizes monocytes/macrophages for hyperproduction of TNF-α.
- tumor necrosis factors
- hypersensitivity
- interferons
- lipopolysaccharides
- lymphocytic choriomeningitis virus
- macrophages
- mice, knockout
- monocytes
- vesicular stomatitis indiana virus
- vesiculovirus
- virus diseases
- infections
- mice
- spleen
- viruses
- sensitization
- human leukocyte interferon
- tumor necrosis
- t-cell activation