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Journal Article
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CDC42 missense mutations and human diseases: from neurodevelopmental disorders to autoinflammation
The Journal of Biochemistry, mvaf021, https://doi.org/10.1093/jb/mvaf021
Published: 29 April 2025
Journal Article
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NMR analysis of interaction between RNA structure elements and small molecules Get access
The Journal of Biochemistry, mvaf020, https://doi.org/10.1093/jb/mvaf020
Published: 28 April 2025
Journal Article
ACCEPTED MANUSCRIPT
Suicide substrate reaction-like modification of mouse serine racemase with L-serine Get access
The Journal of Biochemistry, mvaf019, https://doi.org/10.1093/jb/mvaf019
Published: 22 April 2025
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The relationship between neurodegenerative diseases and α-synuclein levels ... Get access
Published: 16 April 2025
Fig. 3
The relationship between neurodegenerative diseases and α-synuclein levels in patients with PD and DLB. The heart-to-mediastinum (H/M) ratio of 123 I-metaiodobenzylguanidine ( 23 I-MIBG) myocardial scintigraphy is plotted on the horizontal axis, with (A) erythrocyte α-synuclein content (μg/mg) or (
Journal Article
The potential of erythrocyte α-synuclein to differentiate dementia with Lewy bodies from Parkinson’s and Alzheimer’s diseases Get access
The Journal of Biochemistry, mvaf017, https://doi.org/10.1093/jb/mvaf017
Published: 16 April 2025
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α-Synuclein levels in circulating medium and large extracellular vesicles i... Get access
Published: 16 April 2025
Fig. 2
α-Synuclein levels in circulating medium and large extracellular vesicles in patients with neurodegenerative diseases. (A) Representative quantitative Western blotting results using SDS-PAGE for medium/large EV samples (a–h) obtained from 0.5 ml of plasma, along with recombinant α-synuclein standard
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Erythrocyte α-synuclein levels in patients with neurodegenerative diseases.... Get access
Published: 16 April 2025
Fig. 1
Erythrocyte α-synuclein levels in patients with neurodegenerative diseases. (A) Representative quantitative Western blotting results using hrCN-PAGE for erythrocyte cytosol samples (a –f), along with recombinant α-synuclein standards (1–15 ng per lane). This blot serves as a representative example o
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YTHDF1 was upregulated in pancreatic cancer tissues and cell lines. (A) Th... Get access
Published: 11 April 2025
Figure 1
YTHDF1 was upregulated in pancreatic cancer tissues and cell lines. (A) The YTHDF1 mRNA level was significantly increased in pancreatic cancer tissues ( n = 24). (B, C) The YTHDF1 protein expression and quantification were determined in pancreatic cancer tissues, n = 8. (D) The YTHDF1 mRNA level
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Knockdown of SF3B2 decreased YTHDF1-enhanced pancreatic cancer cell prolife... Get access
Published: 11 April 2025
Figure 5
Knockdown of SF3B2 decreased YTHDF1-enhanced pancreatic cancer cell proliferation and invasion. (A) The protein levels of YTHDF1 following overexpression of YTHDF1 in SW1990 and PANC-1 cells. (B) The protein levels of SF3B2 following downregulation of SF3B2 in SW1990 and PANC-1 cells. (C, D) The Ed
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Downregulation of YTHDF1 suppressed pancreatic cancer cell proliferation an... Get access
Published: 11 April 2025
Figure 2
Downregulation of YTHDF1 suppressed pancreatic cancer cell proliferation and invasion. (A) The protein levels of YTHDF1 following downregulation of YTHDF1 by shYTHDF1#1 or shYTHDF1#2 treatment in SW1990 and PANC-1 cells. (B, C) Downregulation of YTHDF1 suppressed SW1990 and PANC-1 pancreatic cancer
Journal Article
YTHDF1 promotes pancreatic cancer cell progression by enhancing SF3B2 translation though m6A modification Get access
The Journal of Biochemistry, mvaf018, https://doi.org/10.1093/jb/mvaf018
Published: 11 April 2025
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YTHDF1 regulates SF3B2 translation in an m 6 A-dependent man... Get access
Published: 11 April 2025
Figure 3
YTHDF1 regulates SF3B2 translation in an m 6 A-dependent manner. (A) Normalized expression of target genes detected by RT-qPCR after (A) RIP and (B) m 6 A-IP, m 6 A negative region of YT CCNB1 was used as the negative control. (C) MeRIP-qPCR detected m 6 A enrichment of SF3B2 5’UTR, CDS, 3’UT
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Upregulation of SF3B2 rescued shYTHDF1-inhibited proliferation and invasion... Get access
Published: 11 April 2025
Figure 4
Upregulation of SF3B2 rescued shYTHDF1-inhibited proliferation and invasion of pancreatic cancer cells. (A, B) Downregulation of YTHDF1 suppressed SW1990 and PANC-1 pancreatic cancer cell proliferation, abrogated by SF3B2. (C, D) Downregulation of YTHDF1 decreased EdU-positive cells in SW1990 and P
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Various PRRs (cGAS, NLRP3, NOD1/2, RIG-I and MDA5) and their associated pro...
Published: 08 April 2025
Fig. 1
Various PRRs (cGAS, NLRP3, NOD1/2, RIG-I and MDA5) and their associated proteins (STING and MAVS) trigger the innate immune signals on the membrane of organelles that include the Golgi, endosomes and mitochondria. Protein palmitoylation emerges as an integral post-translational modification in the a
Journal Article
Innate immune signals triggered on organelle membranes
The Journal of Biochemistry, mvaf016, https://doi.org/10.1093/jb/mvaf016
Published: 08 April 2025
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(A) mEos4b-STING and TBK1-HaloTag7 were stably expressed in STING/TBK1-doub...
Published: 08 April 2025
Fig. 2
(A) mEos4b-STING and TBK1-HaloTag7 were stably expressed in STING/TBK1-double knockout MEFs. A typical overlapped image obtained by simultaneous observation of mEos4b-STING clusters (green, PALM image) and single molecules of TBK1-HaloTag7-SF650T (magenta) 60 min after stimulation with DMXAA. Arrowh
Journal Article
The HP1 hinge region: more than just a linker for heterochromatin
The Journal of Biochemistry, Volume 177, Issue 5, May 2025, Pages 317–319, https://doi.org/10.1093/jb/mvaf005
Published: 27 March 2025
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Model of HP1 binding to DNA and chromatin for its function. The hinge and ...
Published: 27 March 2025
Figure 1
Model of HP1 binding to DNA and chromatin for its function. The hinge and N-terminal CSD regions of Chp2, the yeast homologue of HP1, cooperatively bind DNA to facilitate heterochromatin assembly and gene silencing. Basic amino acid residues (+) in both regions are critical for the DNA binding. For
