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Daniela M Witten, Robert Tibshirani, Scientific research in the age of omics: the good, the bad, and the sloppy, Journal of the American Medical Informatics Association, Volume 20, Issue 1, January 2013, Pages 125–127, https://doi.org/10.1136/amiajnl-2012-000972
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Abstract
It has been claimed that most research findings are false, and it is known that large-scale studies involving omics data are especially prone to errors in design, execution, and analysis. The situation is alarming because taxpayer dollars fund a substantial amount of biomedical research, and because the publication of a research article that is later determined to be flawed can erode the credibility of an entire field, resulting in a severe and negative impact for years to come. Here, we urge the development of an online, open-access, postpublication, peer review system that will increase the accountability of scientists for the quality of their research and the ability of readers to distinguish good from sloppy science.