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Juan Macías, José del Valle, Antonio Rivero, José A. Mira, Ángela Camacho, Nicolás Merchante, Inés Pérez-Camacho, Karin Neukam, Antonio Rivero-Juárez, Rosario Mata, Julián Torre-Cisneros, Juan A. Pineda, on behalf of the Grupo para el Estudio de las Hepatitis Víricas de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI), Changes in liver stiffness in patients with chronic hepatitis C with and without HIV co-infection treated with pegylated interferon plus ribavirin, Journal of Antimicrobial Chemotherapy, Volume 65, Issue 10, October 2010, Pages 2204–2211, https://doi.org/10.1093/jac/dkq272
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Abstract
To evaluate the changes in liver stiffness measurement (LSM) in patients infected by hepatitis C virus (HCV) under pegylated interferon (Peg-IFN) plus ribavirin therapy.
One hundred and forty-three HCV-infected patients, of whom 97 (68%) were also carrying HIV, who started treatment with Peg-IFN/ribavirin were included in this prospective cohort study. The outcome variable of the study was the change in LSM between baseline and the scheduled date for evaluating sustained virological response (SVR).
The median (Q1–Q3) LSM values at baseline and at the SVR assessment date were 8.1 (6.2–11.6) kPa and 6.8 (5.2–9.8) kPa (P < 0.001), respectively. The median (Q1–Q3) decrease between both timepoints was −1 (−2.75, 0.3) kPa. The baseline LSM decreased ≥20% in 37 (46%) patients with SVR and in 19 (30%) without SVR (P = 0.05). In the linear regression analysis, baseline LSM {beta [standard error (SE)] −0.712 (0.044), P = 0.004}, alcohol intake ≥50 g/day [beta (SE) 0.202 (0.030), P = 0.014] and achievement of SVR [beta (SE) −0.238 (0.026), P = 0.029] were independently associated with changes in LSM.
LSM decreases significantly among patients with chronic HCV infection who achieve SVR with Peg-IFN/ribavirin. These patients show a higher frequency of LSM reduction ≥20% at the date of SVR evaluation.
