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Ronald J. Gebhart, Richard J. Duma, Patricia M. Patterson, Jane W. Bagett, Denise S. Williams, Primaxin in the treatment of acute bacterial pneumonia in adults, Journal of Antimicrobial Chemotherapy, Volume 15, Issue 2, February 1985, Pages 233–238, https://doi.org/10.1093/jac/15.2.233
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Abstract
Imipenctn (N-Formimidoyl thienamycin) (MK-0787) is a new β-lactam carbapenem antibiotic. When it is combined with the renal dipeptidasc inhibitor cilastatin (MK-0791) the combination is known as primaxin. In this study 28 adult patients (24 males and 4 females) with acute bacterial pneumonia were treated with primaxin. Twenty-one patients were evaluable and 20 (95%) were clinically cured of their pneumonia. Bacteriological cures were demonstrated in 84% of the cases. One patient with a susceptible Pseudomonas aeruginosa failed. Major complications or toxic reactions included antibiotic associated diarrhoea in one patient; hypotension in one patient; increased grand mal seizures in one patient and elevated liver function studies in one patient. Results of this study suggest that primaxin will be useful in the treatment of a variety of serious Gram-positive and Gram-negative pneumonias. The true incidence of possible toxic reactions with this drug is not known at this time and awaits further experience
- pseudomonas aeruginosa
- hypotension
- bacterial pneumonia
- carbapenem
- adult
- cilastatin
- gram-positive bacteria
- gram-positive bacterial infections
- gram-positive cocci
- gram-positive rods
- lactams
- liver function tests
- pneumonia
- kidney
- imipenem/cilastatin
- tonic - clonic seizures
- antibiotic-associated diarrhea
- toxic reaction