https://orcid.org/0000-0002-0397-7904
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Ganesh Bushi, Muhammed Shabil, Sanjit Sah, Comment on: “The Burden of Psychiatric Manifestations in Inflammatory Bowel Diseases: A Systematic Review With Meta-analysis”, Inflammatory Bowel Diseases, Volume 31, Issue 3, March 2025, Pages 895–896, https://doi.org/10.1093/ibd/izae260
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Dear Editor,
We recently read the interesting article by Massironi et al. titled “The Burden of Psychiatric Manifestations in Inflammatory Bowel Diseases: A Systematic Review with Meta-analysis,” published in Inflammatory Bowel Diseases.1 While the article offers valuable insights into the complex relationship between psychiatric disorders and inflammatory bowel disease (IBD), we would like to raise some methodological concerns and suggest potential improvements to advance research in this critical area.
Our primary concern lies in the lack of clarity regarding the methods used, particularly how the authors converted the hazard ratios provided in several studies, such as those by Ludvigsson JF (2021), Ma S (2023), and Choi K (2019), into odds ratios (ORs) for inclusion in the meta-analysis. While the conversion was found in Figures 2 and 3 of the article, the precise methodology used for this transformation is not described. This omission limits the reproducibility of the study and compromises the transparency of the findings. Including a detailed explanation of the conversion process would greatly enhance the transparency of the methodology and allow future researchers to replicate the approach accurately. Furthermore, the study could benefit from subgroup analyses based on the diagnostic tools used for psychiatric assessments (such as ICD-9 vs. ICD-10) as well as on the study design. These analyses would not only improve the transparency of the findings but also provide a clearer interpretation of the variability observed across the studies included in the meta-analysis.
