https://orcid.org/0000-0001-8577-1864
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Bin Yang, Xiaochang Liu, Qiao Mei, HMGB1-Positive Platelet Microparticles May Be a Biomarker of Inflammatory Bowel Disease, Inflammatory Bowel Diseases, Volume 26, Issue 2, February 2020, Page e10, https://doi.org/10.1093/ibd/izz302
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To the Editor:
Inflammatory bowel disease (IBD) is a group of recurrent chronic nonspecific gastrointestinal inflammatory diseases, and their exact etiology is still unknown. Collins et al.1 found that the platelet activation level increases significantly in the pathophysiological process of IBD, which may require the participation of platelet microparticles (PMPs). PMPs are membrane microparticles released as buds after platelet activation. PMPs have small molecular weight, are easy-to-transmit signals, and participate in immune processes such as autoimmune diseases, infections, and tumors. Platelet microparticles’ formation is often considered a biomarker of inflammatory activity in the body. High-mobility group box 1 protein (HMGB1) is one of the most important signals related to damage-related molecular patterns (DAMP) and is present in various inflammatory cells and in PMPs. It recruits and activates immune cells, stimulates platelet activation, and assists in immune function. Maugeri et al.2 found that the level of PMPs expressing HMGB1 increased, which activated neutrophils and promoted autophagy. To study the expression of PMPs in IBD, we conducted a study to detect the level of PMPs and HMGB1-positive PMPs (HMGB1+-PMPs) in plasma.
