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Joel R. Rosh, Thomas Gross, Petar Mamula, Anne Griffiths, Jeffrey Hyams, Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: A cautionary tale?, Inflammatory Bowel Diseases, Volume 13, Issue 8, 1 August 2007, Pages 1024–1030, https://doi.org/10.1002/ibd.20169
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Abstract
Therapy for the inflammatory bowel diseases increasingly includes the use of immune-modifying and biologic therapies. Recently, in young patients with IBD, an association has been noted between the use of infliximab along with concomitant purine analogues and the development of hepatosplenic T-cell lymphoma (HSTCL)—a rare and all but incurable form of non-Hodgkin's lymphoma. This report briefly reviews the issue of lymphoma and IBD therapy. Additionally, a description of HSTCL and a summary of the known cases of this apparent therapeutic complication are presented. Clinical options in light of this new information are explored.