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Thomas D’Hooghe, Sophie Debrock, Carl Spiessens, Hilde Afschrift, Els Bakelants, Christel Meuleman, Luc Meeuwis, Prospective randomized study on day of embryo transfer, Human Reproduction, Volume 18, Issue 4, April 2003, Page 893, https://doi.org/10.1093/humrep/deg158
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Dear Sir,
We thank Dr Asimakopoulos and Dr Al‐Hasani for their efforts to critically address several issues regarding our study (Van der Auwera et al., 2002).
Firstly, their presumption that there were significant differences between the day 2 group and the day 5 group regarding oocytes, mature oocytes and fertilized oocytes is not true. It can easily be calculated from Table II that there are no differences between the day 2 group and the day 5 group in the mean number of oocytes/patient (10.7 and 11.5), the proportion of mature oocytes/total number of oocytes (84 and 86%) or the percentage of fertilized oocytes/total number of mature oocytes (61 and 65%).
Secondly, we acknowledged in our Discussion that an important weakness was introduced in the study by freezing supernumerary pronucleate ova in group 1 if patients had more than five fertilized oocytes, as has been commented by Dr Asimakopoulos and Dr Al‐Hasani. Even then, the implantation rate per embryo was 39% on day 2 if more than five pronucleate ova were available, suggesting that this bias was limited in nature, i.e. this implantation rate per embryo on day 2 is still among the highest reported in the literature.
