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K Toutouzas, G Benetos, G Oikonomou, I Koutagiar, S Galanakos, M Karmpalioti, N Barampoutis, P Davlouros, V Gata, F Antoniadou, E Siores, D Tousoulis, P6254
The increase of carotid temperatures in patients with documented CAD,under optimal medical therapy,independently predicts MACE: Implications in secondary prevention, European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy566.P6254, https://doi.org/10.1093/eurheartj/ehy566.P6254Close - Share Icon Share
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Introduction: Although the inflammation at baseline predicts clinical events, little is known regarding the impact of inflammatory indexes fluctuation during the follow-up period. Microwave radiometry (MWR), however, allows the consecutive measurements of the internal temperature of carotid arteries as an inflammatory index.
Purpose: To investigate in patients with documented coronary artery disease (CAD),whether changes in carotid artery temperatures are associated with cardiovascular events.
Methods: Consecutive patients with significant CAD as documented by coronary angiography, under optimal medical therapy,from three tertiary centers were included in the study. Maximum carotid plaque thickness was assessed in all carotids by ultrasound. ΔT by MWR was assigned as the temperature difference (maximal minus minimum) along the carotid artery. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up by ultrasound and MWR for two years.
Results: In total 156 patients were included in the study and 312 carotids were analyzed at baseline and at follow up. The mean age was 62.18±10.87 years and 88.5% were men. The median follow-up was 730 days (25% QR 730, 95% QR 1096). The incidence rate of MACE was 18.6% (n=29). At baseline carotid arteries of patients with MACE showed similar ΔT values with carotids of patients without MACE (0.68±0.37 vs 0.66±0.39 °C, p=0.7). However, patients with MACE showed increase in carotid temperatures during follow up (Difmean=0.21±0.53°C, 0.89±0.49 vs 0.68±0.37°C, p=0.008). In contrast, patients without MACE exhibited no significant alteration in carotid temperatures (Difmean=-0.017±0.46°C, 0.64±0.31 vs 0.66±0.39°C, p=0.55). Interestingly, in multivariate logistic regression analysis change in carotid temperatures was an independent predictor of MACE, when adjusted for traditional cardiovascular risk factors (OR=3.37, 95% CI 1.7–6.66, p<0.001).
