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T P W Van Den Boogert, J Vendrik, B E P M Claessen, J Baan, M A Beijk, J Limpens, S A M Boekholdt, R Hoek, R N Planken, J P S Henriques, P6051
CTCA for detection of significant CAD in routine TAVI work-up, a systematic review and meta-analysis, European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy566.P6051, https://doi.org/10.1093/eurheartj/ehy566.P6051 - Share Icon Share
Extract
Background: Transcatheter aortic-valve implantation (TAVI) has evolved to standard treatment of severe aortic stenosis in patients with an intermediate to high surgical risk. Computed tomography coronary angiography (CTCA) could partially replace invasive coronary angiography (CAG) to diagnose significant coronary artery disease (CAD) in the work-up for TAVI.
Objectives: To summarize the available literature on the diagnostic accuracy for CTCA for detection of significant CAD in patients referred for TAVI.
Methods: A literature search was performed in MEDLINE and EMBASE for papers comparing CTCA and CAG in TAVI candidates from inception till December 23, 2017. The primary endpoint was the diagnostic accuracy of CTCA, compared to CAG, for detection of significant (>50% diameter stenosis) CAD in patients referred for TAVI, measured as sensitivity, specificity, positive - (PPV) and negative predictive value (NPV).
Results: A total of 7 studies were included, with a cumulative sample size of 1275 patients. The patient-based pooled sensitivity, specificity, PPV and NPV were 95%, 65%, 71% and 94% respectively.