-
Views
-
Cite
Cite
S. Kimura, S. Nakamura, S. Nakagama, K. Hayasaka, T. Misawa, M. Mizusawa, Y. Yamakami, K. Kojima, Y. Sagawa, H. Ohtani, K. Hishikari, T. Sugiyama, H. Hikita, A. Takahashi, P2367
The impact of systemic pentraxin-3 values on coronary plaque components by optical coherence tomography and outcomes in patients with stable angina pectoris, European Heart Journal, Volume 38, Issue suppl_1, August 2017, ehx502.P2367, https://doi.org/10.1093/eurheartj/ehx502.P2367Close - Share Icon Share
Extract
Background: The long pentraxin family member, pentraxin-3 (PTX3), has been reported to be a useful inflammatory marker for identification of vulnerable plaque components in patients with acute coronary syndrome. However, the relationships between PTX3 and coronary plaque characteristics, and outcomes after percutaneous coronary intervention (PCI) in patients with stable angina pectoris (SAP) remain unclear.
Purpose: We sought to assess the prognostic function of systemic PTX3 values in SAP patients undergoing PCI.
Methods: We investigated 93 SAP lesions with 93 patients with normal pre-PCI high-sensitivity cardiac troponin T (hs-cTnT <0.014ng/ml) undergoing pre-, and post-PCI optical coherence tomography (OCT) analysis. Pre-, just post-PCI, and 24hrs post-PCI systemic PTX3 values were measured. Associations between PTX3 values and plaque components, and outcomes after PCI at the culprit site were evaluated.
Results: Lesions with OCT-derived thin-cap fibroatheroma (TCFA) (fibrous cap thickness <65μm and lipid arc >180°) showed higher values of pre-PTX3 (2.47 (2.02–4.11) vs. 1.86 (1.41–2.72) ng/ml, p=0.04) and peak post-PTX3 (6.67 (3.19–7.33) vs. 3.14 (2.35–4.20) ng/ml, p=0.04) than in those without. Peak values of post-PCI PTX3 were correlated with thinnest fibrous-cap thickness on OCT (r=-0.22, p=0.047) and lipid length (r=0.22, p=0.04). Lesions with irregular tissue protrusion after stenting on OCT showed higher values of peak post-PCI PTX3 than those without (4.76 (3.43–6.97) vs. 2.98 (2.19–4.08) ng/ml, p=0.002). Change of PTX3 values from peak post-PCI to 9- month follow-up correlated to late loss in angiographic lumen diameter (r=0.33, p=0.005). There is no correlation among peak values of PTX3 and hs-cTnT (r=0.13, p=0.22). Values of pre-and post-PCI high-sensitivity c-reactive protein were not associated to coronary plaque components in the present study.
