...-reuse-rights ) Epigenetics Vascular smooth muscle cells Vascular remodelling mRNA N4-acetylcytidine NAT10 Major Science and Technology Project of Yunnan Province 10.13039/501100018531 202302AA310041 Excellent Young Scholars Cultivation Project of Fujian Medical University Union Hospital...

... the original work is properly cited. Chronic kidney disease (CKD) Vascular calcification Vascular remodelling Endothelial activation Calciprotein particles (CPPs) Calcification propensity (crystallization time, T₅₀) Abstract Aims Calciprotein particles (CPPs) are circulating calcium...

... remodelling and may provide an iPSC-free therapy for the treatment of PAH. Graphical Abstract Graphical Abstract This image was created in BioRender.com . Induced pluripotent stem cells Pulmonary arterial hypertension Vascular remodelling Exosomes Pulmonary artery smooth muscle cells Kaohsiung...

... cardiovascular diseases, which increasingly contribute to global mortality, and vascular rejuvenation is geroprotective. However, the epigenetic mechanism underlying ageing-induced vascular remodelling remains unclear. The data obtained from humans and mice demonstrate that the cytoplasmic deacetylase sirtuin 2...

... mice. AngII-induced vascular remodelling, vascular constriction, and increased expression of cell markers of proliferation (PCNA and Ki67) and migration (MMP-2 and MMP-9) were strikingly attenuated in Tagln-Cre-ANGPTL8^fl/fl mice compared with ANGPTL8^fl/fl mice. Furthermore...

... of PAH patients. ⁵ In addition, deleterious variants in BMPR1A were recently identified in four cases of PAH. ⁶ Studies in mice, however, have not yielded a demonstrable role for BMPR1A in pulmonary vascular remodelling, in part due to embryonic lethality seen in the Bmpr1a...

... in the MCT + DMB group, accompanied by improved haemodynamic parameters, decreased right ventricular hypertrophy, and amelioration of pulmonary vascular remodelling. The decrease in abnormal apoptosis, excessive cell proliferation, transforming growth factor-β expression, and restoration of endothelial...

... of vascular macrophages during hypertensive vascular remodelling. Here, we aim at studying the contribution of BMAL1 to the pro-fibrotic macrophage phenotype in the vasculature during hypertension, which leads to enhanced vascular remodelling and promoted blood pressure increase. Methods and results Wild...

... augmented ISG15 expression. Mechanistically, ISG15 induces vascular ROS production, while antioxidant treatment prevented ISG15-induced endothelial dysfunction and vascular remodelling. Conclusion ISG15 is a novel mediator of vascular damage in hypertension through oxidative stress...

... in atherosclerosis is thus far severely lacking, it is crucial to better understand its mechanisms of development. Macrophages Inflammation Calcification Vascular remodelling Atherosclerosis European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie 722609...

... atherothrombosis. Graphical Abstract Graphical Abstract Atherosclerosis Oral anticoagulant agents Calcification Coagulation Vascular smooth muscle cells Vascular remodelling Dutch Thrombosis Society 2014.02 Norwegian Research Council, Nattopharma ASA and the European Union’s Horizon 2020 research...

... and were shown to bind to the endothelial-specific receptor ALK1 with sub-nanomolar affinities, ^{21 , 22} supporting a critical role for BMP9 and BMP10 in vascular remodelling. However, their binding affinities for type 2 receptors differ, ²¹ suggesting that they could also play...

... population to influence the outcomes of pathologic vascular remodelling. Important questions remain regarding the origins of AdvSca1 cells and the essential signalling mechanisms and microenvironmental factors that regulate both maintenance of their stem-like, progenitor phenotype and their differentiation...

... spectrometry; PDGF, platelet-derived growth factor; mTOR, mammalian target of rapamycin; PIP₂, phosphatidylinositol-4, 5-bisphosphate; PI3K, phosphoinositide 3-kinase; PLC, phospholipase C. Proteomics Restenosis Vascular remodelling Genetics Deutsche...

... and results Combination therapy of LCZ 696 and bosentan has additive vascular protective effects against the pulmonary vascular remodelling and PH in two preclinical models of severe PH. Compared with monotherapy, co-treatment of LCZ 696 (30 or 68 mg/kg/day for 2 weeks, per os) and bosentan (100 mg...

... individuals induces measurable remodelling of both heart and vasculature. This amount is age dependent, with predominant cardiac remodelling when younger and predominantly vascular remodelling when older. Physical training cardiac remodelling vascular remodelling healthy ageing ‘Cardiac plasticity...

... mediator changes may serve as a biomarker of the PAH progression and summarize unanswered questions and opportunities for future studies in this area. Graphical Abstract Graphical Abstract Pulmonary hypertension Pulmonary vascular remodelling Endothelial cells Smooth muscle cells Adventitial...

... Jolla, CA, USA). Graphical Abstract Graphical Abstract Pulmonary arterial hypertension Vascular remodelling Animal model Therapeutic target Stromal cell-derived factor 1 Chemokine Pulmonary arterial hypertension (PAH) is a severe and incurable cardiopulmonary condition characterized...

... Resistance artery endothelial function and NO availability might represent important factors involved in resistance artery remodelling, independently from cardiovascular risk factor exposure. Microcirculation Vascular remodelling Endothelial function NO availability Heart Score Increased peripheral...

... investigated whether adipolin modulates pathological vascular remodelling. Methods and results Adipolin-knockout (APL-KO) and wild-type (WT) mice were subjected to wire-induced injury of the femoral artery. APL-KO mice showed increased neointimal thickening after vascular injury compared with WT mice...