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Keywords: tyrosine kinase inhibitor
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Journal Article
Dasatinib-induced pulmonary arterial hypertension complicated with scleroderma: a case report Open Access
Takumi Toya and others
European Heart Journal - Case Reports, Volume 3, Issue 1, March 2019, ytz025, https://doi.org/10.1093/ehjcr/ytz025
Published: 15 March 2019
..., and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Background Although the BCR-ABL tyrosine kinase inhibitor dasatinib is a potent treatment for chronic myeloid leukaemia, it is associated with the risk...
Journal Article
Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension
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Nina Rol and others
Cardiovascular Research, Volume 115, Issue 2, 01 February 2019, Pages 432–439, https://doi.org/10.1093/cvr/cvy186
Published: 18 July 2018
... receptors such as platelet derived growth factor, fibroblast growth factor and vascular endothelial growth factor. Nintedanib, a tyrosine kinase inhibitor targeting primarily these receptors, is approved for the treatment of patients with idiopathic pulmonary fibrosis. Our objective was to examine...
Journal Article
Thrombin receptor expression is increased by angiotensin II in cultured and native vascular smooth muscle cells
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Beate Fisslthaler and others
Cardiovascular Research, Volume 38, Issue 1, April 1998, Pages 263–271, https://doi.org/10.1016/S0008-6363(97)00296-4
Published: 01 April 1998
... on the increase in thrombin receptor mRNA expression was enhanced by the protein kinase C inhibitor Ro 31-8220, but was unaffected by prolonged incubation with phorbol myristate acetate or the tyrosine kinase inhibitors genistein and erbstatin A. Conclusion: These results demonstrate that AII enhances...
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Cardiovascular complications of novel kinase inhibitors
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Mark Sweeney and Alexander Lyon
Published: 01 July 2018
... of the multidisciplinary team in this setting and communication between the cardiologists and the oncologists or haemato-oncologists is invaluable. tyrosine kinase inhibitor hypertension cardiotoxicity thrombosis QT prolongation cardiotoxicity tyrosine kinase inhibitors TKIs angiogenesis inhibitors JAK inhibitors...
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Cancer and cancer therapy
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Dimitrios Farmakis and others
Published: 01 November 2023
... and dysfunction as a result of cachexia in patients with advanced malignancies. anthracycline trastuzumab tyrosine kinase inhibitor RAF–MEK inhibitor immune checkpoint inhibitor radiation-induced heart disease cachexia aetiology of HF anthracyclines cancer therapy related cardiac dysfunction trastuzumab...