...) is associated with a reduced exercise capacity. The role of exercise training in improving chronotropic response (ChR) and functional capacity in these patients remains uncertain. This study assessed the effects of four different exercise programs on peak oxygen consumption (peakVO₂), Kansas City Cardiomyopathy...

... to assess oral diuretic response in outpatients with heart failure (HF). The natriuretic response prediction equation (NRPE) predicts natriuresis following a loop diuretic dose using a urine sample 2 h after the dose and was validated to accurately predict intravenous diuretic response. The primary aim...

... discuss recent advancements in the diagnosis and multidisciplinary management of patients with high-risk PE and highlight the need for rapid and personalized treatment strategies. Acute pulmonary embolism Haemodynamic instability Mechanical circulatory support Pulmonary Embolism Response Teams (PERTs...

... with activity or demand. Chronotropic incompetence, regardless of the method and cut-off adopted to define it, is associated with reduced exercise capacity and a worse prognosis. Furthermore, different pharmacological classes might interfere with the physiologic exercise-induced HR response, thus generating...

... was recorded in the supine position after a few minutes of rest. Heart rate response was continuously monitored during exercise, and HR at 25, 50, 75, and 100% of achieved peak workload was computed. Chronotropic incompetence has commonly been defined with the threshold < 85% of maximal HR or <80% HR...

... is an unresolved and important problem. This study aimed to determine the factors that contribute to cardiac cachexia in a new model of heart failure in mice that lack the integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A. Methods and results Mice were irradiated and reconstituted with bone...

... is poorly understood. This study aims to assess the association of cardiac magnetic resonance (CMR)–derived scar burden and the response of CRT via LBBAP. Methods and results Consecutive patients with CRT indications who underwent CMR examination and successful LBBAP-CRT were retrospectively analysed...

... support Myocardial infarction Hospital rapid response team Multidisciplinary care team Ventricular assist device Cardiogenic shock (CS) is a condition of low cardiac output that accounts for nearly 60 000–70 000 admissions annually in Europe. ¹ Despite the widespread implementation...

... dysfunction in CMs and the heart at the early stage (∼5 weeks post-Fam210a KO). Multi-omics analyses in cKO hearts uncovered chronic activation of the integrated stress response (ISR) as a major component of the gene signature and disease aetiology accompanied by transcriptomic, translatomic...

... Patients who received DAAs had a sustained virologic response rate (SVR) of 90–96%, whereas those treated with interferon-based regimens had a lower SVR of 50%. ⁹ And this higher SVR with DAA therapy has been linked to improved liver-related outcomes such as a reduced risk of liver cirrhosis...

... re-use, please contact [email protected] Abstract Background The ‘double fire’ (DF) atrioventricular (AV) nodal response is a rare mechanism of two ventricular electrical activations following a single atrial beat due to dual AV node physiology. DF AV nodal response is often...

...Yoshihiro Harano; Yoshiaki Kawase; Hitoshi Matsuo; Valentina Rossi; Raheel Ahmed; Elizabeth Paratz; Hikmet Kadioglu; Abdullah Abdullah Hypertrophic obstructive cardiomyopathy Aortic stenosis Pressure wire Pharmacological response Case report Learning Points Evaluation of AS severity...

... popular in research given their cost-effectiveness and potential reach. However, low response rates remain a key contributor to bias and the overall quality of results. Having a well-designed survey, providing financial remunerations, sending personalized invitations, offering regular reminders, and using...

...). In a combined animal and patient study, we investigated if changes in the pulse arrival time (PAT) could be used to measure acute changes in PEP during CRT implantation and hence be used to evaluate acute CRT response non-invasively and in real time. Methods and results In six canines, a pulse transducer...

... in the heart of diabetic mice treated with EMPA compared with diabetic mice. Because sirtuin activation leads to the modulation of cardiomyogenic transcription factors, we analysed the DNA binding activity to serum response elements (SRE) of serum response factor (SRF) by electromobility shift assay. Compared...

...Taishi Dotare; Daichi Maeda; Yuya Matsue; Tsutomu Sunayama; Keisuke Kida; Takeshi Kitai; Nobuyuki Kagiyama; Tetsuo Yamaguchi; Takahiro Okumura; Atsushi Mizuno; Shogo Oishi; Yasutaka Inuzuka; Eiichi Akiyama; Satoshi Suzuki; Masayoshi Yamamoto; Tohru Minamino Poor diuretic response (DR) has also been...

... decrease the burden of catheter-related complications by eliminating the need for multiple atrial punctures. Hypertrophic obstructive cardiomyopathy Propranolol Cibenzoline Pressure wire Pharmacological response Case report Learning points Intravenous propranolol and cibenzoline are helpful...

... infarct size, cardiomyocyte apoptosis, and improved cardiac function ^{160 , 161} INO-1001 STEMI Decreased CRP and IL-6 levels ¹⁶² Atherosclerosis Reduced atherosclerotic lesion development and inflammatory response ^{163 , 164} ATM inhibitor KU55933...

... approach used to develop and refine PROs. Item response theory (IRT) offers promise for addressing measurement problems that have been difficult to solve using CTT. This paper presents foundational concepts in IRT to illustrate how it can be used to improve the development and refinement of PRO measures...

... SIRT1 counteracts doxorubicin-induced cardiotoxicity by mediating Ser139 phosphorylation of histone H2AX, a critical signal of the DNA damage response. Methods and results Doxorubicin (5 mg/kg per week, x4) was administered to mice with intact SIRT1 (Sirt1^f/f) and mice that lack...