..., provided the original work is properly cited. Abstract Aims Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin–angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously...

... to further investigate the sympathetic nervous system–cancer relationships. Many studies have shown that dysregulation of the renin-angiotensin-aldosterone system (RAAS) may promote cancer, mainly driven by the AT1R-Akt axis ( Figure 1 ). ⁸³ The idea for investigating the effects...

... Non-cardiac surgery Major cardiac events Peri-operative care Renin–angiotensin system inhibitors Corresponding author. Tel: +44 20 3594 0351, Email: [email protected] The full list of SPACE trial investigators is provided in the Supplementary data online...

... sites is the deleterious consequence of hypertension and dysmetabolism but, when established, it represents an independent cardiovascular risk factor for MACE occurrence. Graphical Abstract Graphical Abstract Arterial hypertension Major adverse cardiovascular events Renin–angiotensin system...

... failure. However, whether ARNI has renoprotective effects beyond renin-angiotensin system inhibitors alone in cardiorenal syndrome (CRS) has not been fully elucidated. Here, we examined the effects of ARNI on the heart and kidneys of CRS model mice with overt albuminuria and identified the mechanisms...

... coronavirus; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; RAS, renin–angiotensin blocker; SARS, severe acute respiratory syndrome. *Data for five trials [ACEI-COVID (stroke outcome), COVIDMED, PRAETORIAN-COVID, STAR-COVID, and SWITCH-COVID] and subgroup analyses by severity...

... in myocardial stunning with left ventricular wall motion abnormalities typical of TTS. This pathophysiological framework suggests a potential role for long-term treatment with beta-blockers (BBs) and renin–angiotensin–aldosterone system inhibitors (RAASi), albeit in the absence of evidence from randomized...

... Angiotensin II (Ang II) is the most critical endocrine ligand in the renin–angiotensin system. Ang II mediates its signal transduction and functions via the Ang II receptors (ATRs). ⁵ The precise regulation of the Ang II/ATRs axis is crucial for maintaining physiological cardiovascular function...

... effects on blood pressure since it produces the potent vasoconstrictor angiotensin II, and ACE inhibitors (ACEi) are widely used in treating hypertension and other cardiovascular diseases. ³ While ACE and the renin-angiotensin system are important in blood pressure control, recent studies have...

... Hospital, Boston, MA). In the primary pooled analysis, treatment effects of sacubitril/valsartan on the primary endpoint were examined across key subgroups of interest based on age, sex, race, LVEF, eGFR, history of atrial fibrillation or flutter, body mass index, baseline use of renin–angiotensin system...

...-brain natriuretic peptide; RASI/ARNI, renin–angiotensin system inhibitors/angiotensin receptor neprilysin inhibitor; TIA, transient ischaemic attack. Table 1 Main characteristics of the overall study population and divided according to treatments use vs. non-use Total RASI/ARNI Beta-blockers...

.../valsartan and empagliflozin with development of acutely worsening hyponatraemia, both medications were held. Following infusion of hypertonic saline and nephrology consultation, the patient’s sodium improved significantly. Prior to discharge, losartan (50 mg) was added for renin–angiotensin system...

... features appear to be caused by the accumulation of advanced glycation end-products, augmented oxidative stress, inflammatory reactions, and—among others—by an abnormal modulation of the renin-angiotensin system (RAS). ^2–5 As to this last, modulation of the RAS appears to affect post-ischemic...