... Aims Cyclooxygenase-2–derived prostaglandin E₂ (PGE₂) is thought to promote vascular intimal hyperplasia (IH). It has been reported that the PGE₂ receptor EP4 is upregulated in injured vessels and that EP4 signalling in vascular smooth muscle cells (VSMCs) promotes IH...

... rings pre-contracted with a G_q/11-coupled FP/TP (prostaglandin F/thromboxane) receptor agonist, prostaglandin F_2α (PGF_2α; 10 μM), capsaicin first induced transient dilation that was followed by sustained contraction. In endothelium-denuded rings pre-contracted...

... levels are risk factors contributing to impaired vascular function. Previously, in a young ovariectomized rat model, we demonstrated an increase in prostaglandin H synthase (PGHS)-dependent vasoconstriction that could be prevented by estrogen replacement. Subsequently, we found that, with aging, estrogen...

... haemodynamic effects, ¹¹ and data describing the differential effects of inhaled vs intravenouslyadministered prostaglandins in patients withprimary pulmonary hypertension are rare. In this study we compared the acute haemodynamic effects of intravenous iloprost and prostacyclin in patients...

... PAP, pulmonary artery pressure PE, pulmonary embolism PG, prostaglandin PVR, pulmonary vascular resistance TxA₂, thromboxane-A₂ Time for primary review 31 days. Pulmonary embolism (PE) is a frequently encountered disorder, especially in hospital settings. Estimations...

...Pierre Hardy; Isabelle Dumont; Mousumi Bhattacharya; Xin Hou; Pierre Lachapelle; Daya R. Varma; Sylvain Chemtob Blood flow Free radicals Nitric oxide Prostaglandins COX, cyclooxygenase ChBF, choroidal blood flow RBF, retinal blood flow IP₃, inositol 1,4,5-triphosphate NO, nitric...

... such as NO, prostacyclin, and thromboxane are produced in ischemic heart muscle [4–6] . Recently, it has been shown that aspirin, a nonsteroidal anti-inflammatory drug (NSAID), influences the production of NO and some prostaglandins in infarcted heart muscle [7] . Aspirin possesses toxic side effects to gastric mucosa...

... to prostaglandins. In the last control group, the endothelium was removed by perfusion of a bolus of 1 ml air through the lumen. Responses to 1 μM arachidonic acid and 0.1 μM acetylcholine were recorded (n=6). The investigation conforms with the Guide for the Care and Use of Laboratory Animals...

... bridged with various regimens including inotropic support with low-dose dobutamine in conjunction with dopamine and prostaglandin E1. Methods We report on 5 years' experience with prostaglandin E1, a potent vasodilator with proven efficacy in severe heart failure when coupled with catecholamines. From...

...-generated tension production was measured in the smooth muscle of the rabbit ductus arteriosus and compared with two neighbouring fetal blood vessels (main pulmonary artery and aorta). The effect of prostaglandin E₂ (PGE₂), 3-isobutyl-1-methylxanthine (IBMX, a phosphodiesterase...

... are involved in the vascular response to loop diuretics. The role of the renin-angiotensin-aldosterone axis, prostaglandins and the direct vascular effects of loop diuretics on both the arterial and venous parts of the vasculature are discussed. Loop diuretic Furosemide Venodilation Prostaglandin...

...Mary E. Gerritsen Endothelium Prostaglandin Nitric oxide Cyclooxygenase Microcirculation Angiogenesis Indomethacin Aspirin * Tel. (+1-203) 937 2000; Fax (+1-203) 937 0708. 14 12 1995 19 2 1996 Copyright © 1996, European Society of Cardiology 1996 Abstract Eicosanoids are important...

... Myocardial ischemia Indomethacin Dog, anesthetized Exercise Prostaglandin Gwdiovascular Research ELSEVIER CardiovascularResearch 30 (1995) 697-704 Cyclooxygenase...

... 1995 Abstract Objective: The present study utilized a monoculture of vascular endothelium to: (1) determine if nitric oxide (NO) production was decreased during hypoxia, (2) ascertain if specific prostaglandins were released in response to hypoxia, and (3) determine if cyclo-oxygenase inhibition...

...-treated, instrumented dogs served as controls. To address a potential secondary effect of AngII on vascular protein clearance, we monitored lymph prostaglandin E₂ and cGMP (a marker of released nitric oxide, NO). At ≥ 30 min, each dose of AngII was associated with a significant (P...

.... kg⁻¹. min⁻¹) and oral prostaglandin E have been reported to produce fewer complications than higher intravenous doses in the ductal manipulation of congenital heart disease. Over a 3-year period 34 patients were treated with low dosage intravenous or oral prosraglandin. Eighteen (53...

... smooth muscle was dependent on the agent used to induce contraction in the tissue, probably because pregnancy exerted different actions on receptor and voltage operated calcium channels. This effect of pregnancy was independent of either endothelial function or prostaglandin synthesis. Neither pregnancy...

...), and sodium nitroprusside (10⁻⁹ to 10⁻⁷ mol·litre⁻¹) as well as contractile responses to prostaglandin F_2a, (1.7 × 10⁻⁷to5.6 × 10⁻⁴ mol·litre⁻¹) were determined. In all intact strips acetycholine, and A23187 induced similar...

... between humans and pigs. Prostaglandin F_2α; (PGF_2α; 3× 10⁻⁶ mol·litre⁻¹) decreased the flow more substantially in humans (by 74(9)%) than in pigs (by 6(1)%) (p<0.01). A pronounced flow reduction to 0 ml·min⁻¹ was observed in eight of 17 human...

...NOBUYUKI HIEDA; YUKIO TOKI; SATORU SUGIYAMA; TAKAYUKI ITO; TATSUO SATAKE; TAKAYUKI OZAWA ischaemia mitochondria lysosomes prostaglandin I₂ analogue propranolol ABSTRACT Leakage of lysosomal enzymes is associated with irreversible cellular damage. To determine the effect...