... predictive values. Overall, the high-risk Cluster identified more cases but also resulted in more false positives. Precision medicine Primary prevention Cardiovascular disease Epidemiologic methods Age and sex at baseline were available from the Total Population Registry of Sweden. Smoking was self...

... Antiarrhythmic drugs Ablation Digital twins Precision medicine Graphical Abstract Graphical Abstract Abstract In 1924, the Dutch physiologist Willem Einthoven received the Nobel Prize in Physiology or Medicine for his discovery of the mechanism of the electrocardiogram (ECG). Anno 2024, the ECG...

... preventable and, even when disease is manifest, sometimes reversable. Nevertheless, with current clinical and public health strategies, goals of widespread prevention and remission remain largely aspirational. Application of precision medicine approaches that reduce errors and improve accuracy in medical...

...Phyllis M Thangaraj; Sean H Benson; Evangelos K Oikonomou; Folkert W Asselbergs; Rohan Khera Digital twins Generative artificial intelligence Multi-modal models Precision medicine National Heart, Lung, and Blood Institute 10.13039/100000050 R01HL167858 National Institutes of Health...

... Precision medicine Swiss National Research Foundation 33CM30-124112 32473B_163271 Novartis Foundation for Medical-Biological Research 10.13039/501100004784 Swiss Heart Foundation 10.13039/501100004362 Research Prize of the Swiss Society of Cardiology Jubiläumsstiftung...

.... Conclusions These results highlight the potential value of colchicine to mitigate the higher cardiovascular risk of carriers of somatic TET2 mutations in blood cells. These observations set the basis for the development of clinical trials that evaluate the efficacy of precision medicine approaches...

... combined with PAP in OSA. Graphical Abstract Graphical Abstract Hypertension Obstructive sleep apnoea Antihypertensive treatment Precision medicine ESADA Obstructive sleep apnoea (OSA) and hypertension are common disorders associated with an increased risk of major cardiovascular events (stroke...

... drug reactions Precision medicine Musculoskeletal symptoms Corresponding author. Tel: +44 138 238 3874, Email: [email protected] Graphical Abstract Figure. Schematic representation of the definition of cases...

...-metabolism Meta-inflammation GLUT-1 PKM2 Adaptive immunity Precision medicine European Research Council 10.13039/501100000781 ERC-CoG-726318 British Heart Foundation 10.13039/501100000274 FS/4yPhD/F/20/34127A, PG/19/84/34771, FS/19/56/34893A, PG/21/10541, PG/21/10634 Time of primary review...

... and non-executive director of AstraZeneca. PE reports consulting fees from Pfizer, Sanofi Genzyme, Sarepta, Freeline, Bristol Myers Squibb. Polygenic risk scores Genetics Precision Medicine Numerous studies have compared the predictive accuracy of PRS with established clinical risk factors for CAD...

... Precision medicine Nutrition Metabolomics CVD National Institutes of Health 10.13039/100000002 R01 HL136685 K23-HL138260 R01-HL156975 K01-HL127159 R01DK080739 American Heart Association 10.13039/100000968 National Heart, Lung, and Blood Institute 10.13039/100000050 University...

... characterization of the patient, making a precision medicine built on the single individual feasible. References 1 Mcdonagh TA , Metra M , Adamo M et al 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure . Eur Heart J 2021 ; 42 : 3599 – 3726 . 2...

..., including diagnostic and monitoring techniques. Such an approach could enable the refocusing of healthcare from intermittent contacts and intervention-only focus to a more holistic patient view. Personalized healthcare Precision medicine Artificial intelligence Diagnostic technologies Remote patient...

... understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system. Cardiology Vascular Biomarkers Precision medicine This article...

... in the ADCY9 gene. CI, confidence interval; CV, cardiovascular; HR, hazard ratio. Precision medicine Atherosclerosis Myocardial infarction CETP Adenylate cyclase type 9 (ADCY9) Genetics Written informed consent was obtained from all patients before enrolment. Blinded randomization was centralized...

... and energy production. Finally, PPi rescued DCM phenotype in multiple gene mutations associated to DCM. Induced pluripotent stem cells Cardiomyocytes Drug screening Dilated cardiomyopathy Clinical-trial-in-a-dish Precision medicine Phenotypic screens NIH 10.13039/100000002 R01 HL139679 R01...

..., CYP2C19-guided P2Y₁₂ inhibitor selection can improve CV outcomes and lower costs for the VHA within 12 months of implementation. CYP2C19 testing Precision medicine Pharmacogenomics Veterans NIH 10.13039/100000002 For patients with acute coronary syndromes (ACSs) who have undergone...

... Precision medicine UK Wellcome Trust, Medical Research Council, Department of Health Scottish government, and Northwest Regional Development Agency Welsh Assembly Government and British Heart Foundation Nuffield Department of Population Health, Oxford University British Heart...

... from usual care to biomarker-based personalized treatment and precision medicine in HF. This transition must rely on the biomarker-guided identification of the diverse histomolecular phenotypes of cardiac fibrosis and, accordingly, on the individualization of anti-fibrotic therapies. Since cardiac...

... to harness potential diagnostic, prognostic, or therapeutic targets. Such novel treatments are needed for cardiovascular precision medicine, i.e. to induce angiogenesis, prevent ischaemia/reperfusion injury and stimulate cardiomyocyte regeneration in heart failure. Conflict of interest: None declared. G.C...