...Tongyao Zhang; Yajie Liao; Jitao Ling; Jing Zhang; Deju Zhang; Xiaoping Yin; Peng Yu; Xiao Liu Microplastics Nanoplastics Cardiovascular diseases Endothelial cell toxicity Oxidative stress Atherosclerosis Inflammatory pathways Coagulation dynamics Thrombus formation Immune cell function...

... ferroptosis GSTP1 atrial fibrillation oxidative stress ACCEPTED MANUSCRIPT 1 GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating 2 ferroptosis 3 Han Li1,2 Zhenyu Feng1 Benke Li3 , Jie Bai4, Qiu-yue Lin1, Xiaohong Yu1, 4 Ningning Zhang1 Yunpeng Xie1 Xiaolei Yang1,# 5 1 The first...

... or 24 h of reperfusion. C57BL/6J mice underwent 30′ of ischaemia, followed by 10′, 2, 12, 24 h, or 4 weeks of reperfusion. Hearts and isolated cardiomyocytes (CMs) were analysed for gene expression. We assessed cardiac function, infarct size (IS), oxidative stress, and fibrosis in mice subjected...

... administration were protected from myocardial injury, cardiac dysfunction, and fatality in response to DOX. A significant reduction in both oxidative stress and cardiomyocyte apoptosis induced by DOX injection was also observed in the presence of TZP. Consistently, results obtained from in vitro studies...

... with the AT1R/NADPH oxidase pathway to cause eNOS-NO/ROS imbalance. Graphical Abstract Graphical Abstract Cardiovascular disease SGLT2 Pro-inflammatory cytokines Local angiotensin system Oxidative stress Endothelial dysfunction Nitric oxide (NO) formation in ECs was determined using the NO probe, DAF-FM...

... describes how alterations in the intrauterine environment during maternal obesity, such as foetal hypoxia and hyperinsulinaemia ^{34 , 35} can lead to oxidative stress, ^{20 , 36} mitochondrial dysfunction and metabolic inflexibility, ^{26 , 37–41} contributing to sympathetic...

... MLL1-induced activatory trimethylation of histone H3 at lysine 4 (H3K4me3) in the promoter region of NF-κBp65 and NOX4 genes leads to their upregulation and downstream inflammation and oxidative stress. Enrichment of H3K4me3 in the NF-κBp65 promoter persists in PBMC collected from...

... ROS and caused inflammation in adipose tissue in the HFD model. RNA-sequencing data and alteration of gene pathway clusters also supported additive damage by noise in the setting of diabetes. Conclusion In all three models of diabetes, aircraft noise exacerbates oxidative stress, inflammation...

... through cGMP-PKG signalling pathway, and it is a promising therapeutic and predictive target of cardiac I/R injury. Graphical Abstract Graphical Abstract Apoptosis Ischaemia/reperfusion injury Oxidative stress Isthmin-1 cGMP-PKG Natural Science Foundation of Hubei Province 10.13039/501100003819...

... viability. ⁵⁴ Reduced levels of oxidative stress preserve mitochondrial DNA and reduce mitochondrial fission 1 (Fis1) protein activation, again modulating mitochondrial fission. ⁵⁵ Also, dapagliflozin was reported to facilitate the opposite mechanism of mitochondrial fusion...

... of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk^−/− mice are susceptible to atrial fibrillation (AF) and that rs3184504 is associated with AF and AF-related stroke in humans. During inflammation, reactive lipid dicarbonyls are the major components of oxidative...

... of cardiomyocyte p62 displayed hypoxia-induced contractile dysfunction, oxidative stress, and cell death. Mechanistically, p62-depleted hearts exhibit impaired Hif-1α and Nrf2 transcriptional activity. Because findings from these two murine models suggested a cardioprotective role for p62, mechanisms were...

... for microRNA (miRNA) biogenesis; and (iv) overall impairment of miRNA biogenesis, which negatively impacts HF outcome. Blue and red arrows/inhibitors represent the vicious cycle of HF and the benefits of small molecule activators of ALDH2 in HF, respectively. Oxidative stress Aldehyde Mitochondria Therapy...

... unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Graphical Abstract Graphical Abstract Oxidative stress Endothelial function Adipokine Adipose tissue Cross-talk Deutsche Forschungsgemeinschaft 10.13039/501100001659 LI-1042/5-1 (H.L...

... Findings from the current study have the potential to fill in gaps in the missing heritability of AAA. Moreover, there may be future benefits in the preventive work if investigating the role of antioxidant vitamin intake takes sex-related and oxidative stress–related genetics into account in intact AAA...

... production aggravated by noise exposure prior to cardiac ischaemia. Created with BioRender.com. Noise pollution Aircraft noise Oxidative stress Endothelial dysfunction Inflammation Myocardial infarction Boehringer Ingelheim Foundation 10.13039/501100008454 German Federal Ministry for Education...

... of fine particles on major adverse cardiovascular events. Most of the available evidence concerns the effects of exposure to PM with a diameter of <2.5 µm (PM2.5) and the risk of developing coronary heart disease through inflammation and oxidative stress. While prolonged exposure to PM2.5 has been...

... experimental analyses and treatment conditions and correlated to oxidative stress, senescence, and ploidy in adult murine CICs. Surface Lin28A expression is present on 5% of fresh CICs and maintained through Passage 2, increasing to 21% in hyperoxic conditions but lowered to 14% in physiologic normoxia...

... online . Myocardial infarction Ischaemic heart disease Protein methylation Oxidative stress Hippo pathway Sheikh Khalifa bin Hamad Al Thani Foundation University of Zürich 10.13039/501100006447 Swiss National Science Foundation 10.13039/501100001711 Swiss Heart Foundation...

...) and LDLR^−/− (n = 9–16/group) mice that had received single IV injections compared with saline-treated controls. Again, ferumoxytol treatment (1 mg Fe/kg) failed to induce apoptosis or oxidative stress in these tissues. Concomitant antioxidant treatment (EUK-8/EUK-134) largely prevented...