... of necrotic core (NC), a major feature responsible for plaque disruption, is likely the consequence of accelerated macrophage apoptosis coupled with defective phagocytic clearance (efferocytosis). The cleavage of the extracellular domain of Mer tyrosine kinase (Mertk) by metallopeptidase domain17 (Adam17) has...

... parameters in a consecutive series of 473 male patients: fibrous, fibro-fatty, dense calcium (DC), necrotic core (NC), and a calculated NC/DC ratio. Patients’ age was 61 ± 11 years, with 27% smokers and 69% having a lipid disorder. The NC/DC ratio was the only VH-IVUS parameter related to both TC/HDL ratio...

... quantification of the necrotic core in contact with the lumen (NCCL). (A) The original virtual histology-intravascular ultrasound cross-sectional area. (B) The blue area was selectively quantified as the major confluent NCCL areas and blue plus purple areas indicate total NCCL areas...

... necrotic core expansive remodelling atherosclerotic plaques coronary artery disease cholesterol thin cap fibroatheroma CT coronary angiography macrophages gadofluorine enhanced imaging magnetic resonance imaging MRI molecular imaging FDG PET iron oxide particles nuclear imaging see also...