...Domenico Galante; Giulia La Vecchia; Antonio Maria Leone; Filippo Crea In recent decades, the paradigm of obstructive epicardial coronary artery disease as a cause of myocardial ischaemia has been integrated with scientific evidence that supports the existence of a more complex scenario in which...

...-reuse-rights ) Abstract Aims Activation of the transcriptional factor Krüppel-like factor 5 (KLF5) is detrimental to chronic heart failure. We explored the involvement of KLF5 in myocardial ischaemia/reperfusion injury. Methods and results Yorkshire pigs underwent 75′ of ischaemia, followed by 3...

... or may not co-exist with obstructive epicardial coronary atherosclerosis and that ‘different mechanisms of ischaemia may act concomitantly’. ¹ For the first time, angina and non-obstructive coronary arteries (ANOCA) and ischaemia and non-obstructive coronary arteries (INOCA) are recognized...

... ventricular apex at apical four-chamber view on myocardial contrast echocardiography during mental stress testing. The right panel (C) shows reduced values of left ventricular ejection fraction and global longitudinal strain. Figure 4 Mental stress-induced myocardial ischaemia diagnosed on PET...

... and residential green exposure on non-invasively derived coronary obstruction and myocardial ischaemia. Methods and results Consecutive patients screened by coronary computed tomography angiography (CCTA) for stable chest pain between 1 January 2019 and 31 December 2020 were included in a registry. Exposure...

... [email protected]. Abstract Background Pericardial agenesis is one of the rarest cardiac anomalies, often asymptomatic, but, in some cases, causes chest symptoms and, in worst cases, fatal complication. We experienced a case of a pregnant woman with myocardial ischaemia due to a pericardial agenesis...

... ischaemia. Therefore, the clinical utility of ΔT1 in a real-world cohort of patients to detect obstructive CAD is limited. Graphical Abstract Graphical Abstract This study compared CMR-derived ΔT1 and QP measures, evaluated the influence of sex and comorbidities on ΔT1, and assessed the diagnostic...

... sheep were evaluated during open-chest surgery. Epicardial multiframe SWE acquisitions were performed in short-axis view simultaneously with haemodynamic acquisitions during inferior vena cava occlusion, aortic clamping, atrial pacing, and ischaemia–reperfusion. The cyclic variation in the median value...

... implications of missed or delayed diagnosis are myocardial ischaemia and risk of sudden cardiac death. Improvement in non-invasive imaging has made diagnosis and surgical planning possible with multi-modal imaging. Case summary A 12-year-old boy with ischaemic chest pain caused by isolation of the left...

... using a standard 17-segment, 5-point scoring system to determine summed rest, stress, and difference scores, reflecting scar, ischaemia plus scar, or ischaemia, respectively. Absolute global myocardial blood flow (MBF, mL/min/g) was measured at rest, and peak vasodilator-induced hyperaemia and dynamic...

... by myocardial ischaemia–reperfusion (MI/R) injury. Higher levels of circulating arachidonic acid (AA) are reportedly associated with lower risk of cardiovascular disease. The cyclooxygenase (COX) pathway metabolizes AA into prostaglandins (PGs) and the platelet-activating thromboxane A₂...

.../ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Ischaemia Ischaemic heart failure Percutaneous coronary intervention Magnetic resonance imaging National Institute for Health and Care Research Health Technology Assessment...

... targeting autonomic dysfunction may improve CVD outcomes. Structured graphical abstract Structured graphical abstract Epidemiology Myocardial ischaemia Autonomic nervous system National Heart, Lung and Blood Institute 10.13039/100000050 F32HL154707 T32HL139439 R01HL163998 R01HL155711...

...-of-function studies in genetic mouse models revealed that ZEB2 expression in cardiomyocytes is necessary and sufficient to protect the heart against ischaemia-induced diastolic dysfunction and structural remodelling. Moreover, RNA sequencing of ZEB2-overexpressing (Zeb2 cTg) hearts post-injury implicated ZEB2...

... Antianginal therapy Antithrombotic therapy Atherosclerosis Clinical likelihood Chronic coronary syndromes Coronary artery disease Diagnostic testing/algorithm Heart team Lipid-lowering therapy Microvascular disease Myocardial ischaemia Myocardial revascularization Outcomes PROMS/PREMS Shared...

... dissection Aortic surgery Carotid artery disease Chronic limb-threatening ischaemia Endovascular repair Exercise Genetic aortic diseases Intramural haematoma Lower extremity artery disease Penetrating atherosclerotic ulcer Peripheral arterial disease Polyvascular disease Renal artery disease 1...

... coronary artery. The patient experienced relief from chest pain and was discharged 19 days after the surgery. Discussion A right coronary sinus of Valsalva aneurysm, which caused right coronary artery ischaemia, was successfully treated using a modified Bentall procedure. Coronary computed tomography...

... artery disease; CCTA, coronary computed tomography angiography; CV, cardiovascular; FU, follow-up; MI, myocardial infarction; NRI, net reclassification improvement. Atherosclerosis CCTA Ischaemia Artificial intelligence Plaque Coronary artery disease 10.13039/501100012264 U01HL105907 U01HL105462...

... intracellular Na⁺ concentration ([Na⁺]_i) reaches pathophysiological levels. Elevated [Na⁺]_i is a major determinant of the ischaemia and reperfusion (I/R)-induced myocardial injury; thus, we hypothesized that Slack plays a role under these conditions...

... myocardial ischaemia/reperfusion (I/R) injury, whereas their exact functions are unclear. Here, we investigated the roles of circCHSY1 in the acute myocardial I/R injury and the potential mechanisms involved. Methods and results The expression of circCHSY1 was detected in cardiomyocytes from mouse, rat...