... (0.9) 14.4 (1.0) 14.1 (0.9) 14.1 (0.8) 14.0 (0.9) < 0.001 Iron deficiency or anaemia treatment, n (%) 107 (3%) 33 (4%) 24 (3%) 21 (2%) 29 (3%) 0.51 ^aExpressed as mean (standard deviation). Table 3 Associations of plasma hepcidin level with measures...

... Background and Aims Evidence is lacking that correcting iron deficiency (ID) has clinically important benefits for patients with heart failure with preserved ejection fraction (HFpEF). Methods FAIR-HFpEF was a multicentre, randomized, double-blind trial designed to compare intravenous ferric...

..., contributing to the evidence on the subject. It underscores the importance of further research into anaemia as a potential target for intervention in this patient group. Aortic valve replacement Transcatheter aortic valve implantation Anaemia Atrial fibrillation Heart failure Iron deficiency Abstract...

... tests for iron deficiency, including anaemia, and the response to intravenous iron in patients with heart failure? Methods In the IRONMAN trial, 1137 patients with heart failure, ejection fraction ≤ 45%, and either serum ferritin < 100 µg/L or transferrin saturation (TSAT) < 20% were...

... will introduce the relationships between hypoxia and cardiomyocyte iron deficiency, discuss the experimental evidence that correlates MID with the worsening of myocardial ischaemia and post-ischaemic remodelling, and propose molecular mechanisms that may underpin these effects. In patients with heart failure (HF...

...; HR, hazard ratio; PBO, placebo, RR, rate ratio; TSAT, transferrin saturation. Heart failure Acute heart failure Chronic heart failure Ferric carboxymaltose Iron deficiency CSL Vifor See the editorial comment for this article ‘Intravenous iron repletion in heart failure: bridging the gap between...

... the functional importance of cardiac iron status after MI and the potential of pre-emptive iron supplementation in preventing cardiac iron deficiency (ID) and attenuating left ventricular (LV) remodelling. Methods and results MI was induced in C57BL/6J male mice by left anterior descending coronary artery...

..., iron deficiency, diabetes, atrial fibrillation . Eur J Prev Cardiol 2020 ; 27 : 27 – 34 . 2 Loncar G , Obradovic D , Thiele H, von Haehling S, Lainscak M. Iron deficiency in heart failure. ESC Heart Fail 2021 ; 8 : 2368 – 2379 . 3 Núñez J , Comín-Colet J...

...; the PVDOMICS Study Group Table 1 Baseline features of patients with or without iron deficiency across the PVD spectrum Parameter Pulmonary hypertension (n = 693) PVD comparator (n = 335) TSAT ≥21 (n = 266) TSAT <21 (n = 427) P-value TSAT...

[email protected] Based on this epidemiological and pathophysiological basis, correction of iron deficiency has become an important goal in the management of heart failure. Several clinical trials have been conducted to examine the impact of oral or intravenous iron supplementation in heart failure with reduced...

... to the bloodstream and also the release of recycled iron from macrophages in the spleen and the liver, potentially leading to iron deficiency. Created with BioRender.com Adapted from Nat Rev Cardiol 2015; 12: 659–669. ⁵ There are limited data on the natural history of ID and the trajectories of ID...

... Iron deficiency Cardiac remodelling Contractility Heart failure Randomized controlled trials The methods and design of IRON-CRT have been published previously. ⁹ Briefly, the IRON-CRT trial was an investigator-initiated, double-blind, randomized, placebo-controlled trial conducted...

...://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Aims Patients with heart failure (HF) and iron deficiency...

... but no ID/A+ID+, anaemia and ID/A−ID+, ID but no anaemia; A, anaemia; BMI, body mass index; BNP, brain natriuretic peptide; COPD, chronic obstructive pulmonary disease; ID, iron deficiency; LVEF, left ventricular ejection fraction; MDRD, Modification of Diet in Renal Disease formula; N, number...

... major non-cardiovascular comorbidities of heart failure, anaemia and iron deficiency, and diabetes mellitus, and on the most important cardiovascular associated condition of heart failure patients, atrial fibrillation, focusing the attention on the clinical and prognostic impact of those conditions...

.... The variables associated with TAPSE, TAPSE/PASP, and LVEF were evaluated by multivariate linear regression analysis. The contribution of the exposures to the proportion of the dependent variable variation was evaluated by R². Iron deficiency (ID), a common condition in patients with heart...

...; ICU: intensive care unit; ID: iron deficiency; LDH: lactate dehydrogenase; MCH: mean concentration haemoglobin; MCV: mean cell volume; NYHA: New York Heart Association; RBC: red blood cell. Data expressed as mean (standard deviation), median (interquartile range) or number (%). °For valve surgery...

...://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Aims Iron deficiency (ID) is common in heart failure (HF) patients...

... reversible cause of anaemia. Among tested patients, criteria for iron deficiency, vitamin B12 deficiency, and/or hypothyroidism, were met in 29.7%, 3.2%, and 18.6% of patients, respectively. At least one potentially reversible cause of anaemia was identified in 25.8% of tested patients, and diagnostic...

.... Wollert; Tibor Kempf Iron deficiency (ID) is a frequent comorbidity in heart failure (HF). ¹ Based on serum markers of depleted body iron stores, reduced systemic iron availability, and unmet cellular iron requirements, ∼40% of patients with chronic HF and up to 75% of patients with acute...