... of MRAP2 in MC4R neurons, with a particular focus on autonomic and cardiovascular functions. Methods and Results Selective deletion of MRAP2 in MC4R neurons causes obesity that was associated with hyperphagia and impairment in glucose homeostasis and insulin sensitivity. MC4R agonist Melatonan II (MTII...

... hypertension may be activated by increased RV workload. Glucose and insulin actions have been well-documented in the LV myocardium. However, RV glucose metabolism has not been fully investigated. There is no evidence to support broad conclusions about FDG-PET imaging protocols or myocardial metabolism...

... Imrie; Katherine Bridge; David J Beech; Stephen B Wheatcroft; Mark T Kearney; Richard M Cubbon Insulin-like growth factor-1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that regulates cell survival, growth, and metabolism. ⁶ Its cognate receptor tyrosine kinase (IGF-1R...

...) Medications  Statins 312 (55.6) 191 (50.8) 121 (65.4) 0.001 Glucose metabolism  Glucose, mg/dL 103.23 (22.99) 101.93 (22.25) 105.51 (24.14) ns  Insulin, pmol/L 89.09 (126.69) 93.46 (144.94) 80.40 (78.35) ns Lipids metabolism  Total-cholesterol, mg/dL 176.28 (66.27) 173.72...

..., and excessive expense. ²⁹ Consequently, various alternative non-insulin-based measures of IR combined with simple routine biochemical or anthropometric indicators are developed. In this study, two well-established IR indices, including TyG and METS-IR, were used for IR assessment. ^{30 , 31}...

... of atherosclerotic cardiovascular disease, independent of lipid-lowering medication. BMI, body mass index; CI, confidence interval; HDL-C, HDL cholesterol; LDL-C, LDL-cholesterol; OR, odds ratio. Dyslipidaemia Adiposity Insulin resistance Atherosclerosis All analyses were conducted separately in adults...

...% in HFD-fed vs. NC-fed ApoE^−/− mice (Figure 1 A and B), and IR protein levels were undetectable in SMIRKO/ApoE^−/− mice (Figure 1 D). Insulin signalling, assessed by Akt phosphorylation (p-Akt) in the aorta, showed insulin-induced p-Akt reductions of 50...

... an increased cardiovascular risk. Frailty is very common in hypertensive patients, and insulin resistance has been linked to frailty in older adults with diabetes. On these grounds, our aim was to evaluate the association between insulin resistance and cognitive impairment in hypertensive and pre-diabetic...

... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Cardiogenic shock Mechanical circulatory support Hyperglycaemia Cardiac critical care IABP Impella VA-ECMO Diabetes Insulin In line...

.../standard_publication_model ) Clopidogrel Insulin autoimmune syndrome Hypoglycaemia Antiplatelet therapy Pharmacovigilance study Drug safety Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-023 Upon FAERS data mining, we identified 57 reports of clopidogrel-associated IAS...

... with defective insulin actions or signalling, altered cardiac glucose and/or FA utilization, enhanced oxidative stress, and/or cardiac fibrosis. ^{75 , 84} The most popular animal models include the chemical ablation of the β-cells of the pancreas by streptozotocin, genetic interference with leptin...

... and cardiometabolic risk factors [including HOMA-IR, BMI, TC, LDL-c, HDL-c, systolic blood pressure (SBP), diastolic blood pressure (DBP), and eGFR]. Abstract Aims We aimed to investigate whether the triglyceride–glucose (TyG) index, an easy-calculated and reliable surrogate of insulin resistance, was associated...

...N Cauwenberghs; M Prunicki; F Sabovcik; D Perelman; K Contrepois; X Li; M P Snyder; K C Nadeau; T Kuznetsova; F Haddad; C D Gardner 2636 Preventive Cardiology Risk Factors and Prevention, Diabetes and the Heart, Metabolic Syndrome, Insulin, Insulin Resistance The association of soluble ACE2...

..., Insulin, Insulin Resistance 2642 Preventive Cardiology Risk Factors and Prevention, Diabetes and the Heart, Metabolic Syndrome, Insulin, Insulin Resistance The signi cant role of coronary artery calci cation score in asymptomatic patients with metabolic syndrome M. Temtem1, M. Serrao2, M.I. Mendonca1, M...

...A F Bestavashvili; A L Bestavashvili; I Dhif; D Tuter; D Gognieva; D Glushenkov; C Pavlov; P Chomahidze; A Sirkin; P Kopylov 2646 Preventive Cardiology Risk Factors and Prevention, Diabetes and the Heart, Metabolic Syndrome, Insulin, Insulin Resistance Evaluation of the effects of interval...

...M Kouvari; C Chrysohoou; E Georgousopoulou; J Skoumas; C Pitsavos; D B Panagiotakos; C S Mantzoros Metabolic Syndrome, Insulin, Insulin Resistance Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email...

...) (n=46, men (M) – 37,0%, av.age 40 [34; 43]), and MS (n=70, M – 81,4%, av.age 40 [35; 44]). Height, weight, BMI, waist circumference, blood tests (fast glucose (FG) and glucose tolerance (GT), lipid profile, insulin, adiponectin (ELISA, Mediagnost), leptin (ELISA, DBC), FGF21 (ELISA KIT, BCM...

... of diabetes (normoglycaemic) with similar demographical and clinical characteristics. Glucose and insulin levels, pulse wave velocity (PWV-Complior, ALAM), central systolic blood pressure (cSBP) and augmentation index (AI) were measured at baseline, 30, 60, 90 and 120min during OGTT. Perfused boundary region...

... of visceral fat around myocardium contributes to exercise intolerance. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): National University Corporation Tsukuba University of Technology education and research Grant Metabolic Syndrome, Insulin, Insulin...

... and in healthy controls. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): ASST Grande Ospedale Metropolitano Niguarda Metabolic Syndrome, Insulin, Insulin Resistance 2640 Preventive Cardiology Risk Factors and Prevention, Diabetes and the Heart, Metabolic...