... are joint senior authors. Corresponding author. Tel: +65 65166719; fax: +65 6221 2534, E-mail: [email protected] Hydralazine Cardioprotection Acute myocardial ischaemia/reperfusion injury Mitochondrial fission Stafford Fox Medical Research Foundation Victorian Government 10.13039...

... inf 121±3 – 128±4 – 373±19 – 374±15 – Pinacidil 126±3 −47±3 124±4 −40±3 374±12 +27±5 389±11 +28±5 Hydralazine 127±4 – 114±5 – 412±15 – 406±11 – Phenylephrine 118±5 +57±3 120±5 +51±2 356±14 −52±6 355±15 −30±5* All values are means±S.E.M., n=10; Δ...

... blood pressure and left ventricular hypertrophy of hydralazine and lisinopril we studied 30 patients, all , nales, still hypertensive (diastolic blood pressure ≤ 95 mmHg) despite combined beta-blockerldiuretic therapy and with echocardiographic evidence of left ventricular hypertrophy (left ventricular...

... before occlusion and also ended at 60 min of reperfusion (group B). In a further seven animals bimakalim infusion was started 15 min before coronary occlusion, but was stopped at the onset of ischaemia (group C). In the fourth group of animals (n = 7), a hydralazine infusion (0.2 mg·kg⁻¹ over...

...R. Dietz; J. Manthey; K. J. Osterziel; N. Röhrig; A. Schömig; A. Haass; W. Kübler © 1988 The European Society of Cardiology 1988 Abstract Administration of hydralazine and isosorbide dinitrate leads to a reduction of one-year mortality by 38%. However, a major disappointment has been...

..., European Society of Cardiology 1988 ABSTRACT The direct cardiac effects of hydralazine were studied in isolated working rat heart, isolated cat right ventricular papillary muscle, and isolated rabbit right atrium. The haemodynamics, myocardial energetics, and contractility of isolated hearts were...

...J. N. Cohn; The Veterans Administration Cooperative Study Group © 1988 The European Society of Cardiology 1988 Abstract The reduction of mortality in patients with chronic congestive heart failure treated with the vasodilator regimen hydralazine and isosorbide dinitrate compared to those treated...

... of Cardiology 1986 Cardiovascular Research, 1986, 20, 215-220 Correlation between effects of hydralazine on force and on the adenyl cyclase system of ventricular myocardium in dogs and cats BABETH RABINOWITZ,* WILLIAM W PARMLEY,? YADAEL HAR-ZAHAV,* ELLA...

...ANTHONY B EBEIGBE; C PETER ALOAMAKA * Address for correspondence and reprint requests: A B Ebeigbe. PhD. Department of Physiology, College of Medical Sciences, University of Benin, Benin City, Nigeria Copyright © 1985, European Society of Cardiology 2003 SUMMARY The effect of hydralazine...

... to treatment with either hydralazine (mean 127 mg/day, range 37–225) or placebo. Eight patients in the hydralazine group and ten patients in the placebo group completed the study. Two of the patients in the hydralazine group and one patient in the placebo group were withdrawn because of suspected side effects...

...W. Rutishauser Congestive heart failure prazosin hydralazine Requests for reprints to Prof W Rutishauser, Center of Cardiology, University Hospital, CH-121 Geneva 4. Switzerland © 1983 The European Society of Cardiology 1983 Abstract In the last two years, six studies using prazosin...

... of Medicine, 1300 Morris Park Avenue, Forchheimer Building-Room 715, Bronx, New York 10461, U.S.A. 25 3 1980 © 1980 The European Society of Cardiology 1980 Abstract Hydralazine, 200 to 400 mg daily, was administered orally to 20 consecutive patients with severe heart failure. After 24 h of continuous...

...D. MATHEY; P. MANRATH; J. POLSTER; G. WITTE; R. MONTZ; W. BLEIFELD Abstract To test the acute and chronic, effects, of oral hydralazine (HD) on left ventricular (LV) pump function and renal hemodynamics, we administered it to patients with chronic left heart failure. After 6 days of HD- therapy (n...

...European Society of Cardiology The use of hydralazine and isosorbide dinitrate in combination with renin–angiotensin blockade and evidence-based beta-blocker therapy is an accepted therapy for heart failure with reduced ejection fraction (HFrEF). However, differing assessments of the evidence base...