.... E-mail address: [email protected] ; [email protected] (C.-T.T) Graphical Abstract Graphical Abstract Atrial fibrillation • Genome-wide association study • Transcriptome-wide association study • Expression quantitative trait locus • Whole genome • Taiwan Biobank • Taiwanese • Taiwan...

.... Methods and results Whole genome sequencing data generated by the 100 000 Genomes Project (100KGP) included 536 FH patients diagnosed using the FH Simon–Broome criteria. Rare variants in known FH genes were analysed. Genome-wide association study between 443 FH variant-negative unrelated FH cases and 77...

... Coronary artery disease (CAD) poses a substantial threat to global health, leading to significant morbidity and mortality worldwide. It has a significant genetic component that has been studied through genome-wide association studies (GWAS) over the past 17 years. These studies have made progress...

... Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background and Aims Brugada syndrome (BrS) is an inherited arrhythmia with a higher disease prevalence and more lethal arrhythmic events in Asians than in Europeans. Genome-wide association studies (GWAS) have...

... Cardiovascular disease Type 2 diabetes mellitus Mendelian randomization Genome-wide association studies Corresponding author. Tel: +8613437253673, Email: [email protected] Conflict of interest: None declared. 23 12 2023 26 02 2024 15 03 2024 04 04 2024 © The Author(s) 2024. Published...

... Heart rate/genetics Genome-wide association study/methods Cardiovascular diseases/genetics Risk factors Polymorphisms single nucleotide Atrial fibrillation Cardiomyopathy dilated Hypertension The Liaison Committee Central Norway and Norwegian Health Association NTNU Biotechnology...

..., genome-wide association study; LDL, low-density lipoprotein. Aortic stenosis Genome-wide association study Mendelian randomization Phenome-wide association study Gene expression Genetic risk score Fonds de Recherche du Québec—Santé 10.13039/501100000156 CX00180 US Government or the US...

... pressure Mendelian randomisation Brain Genome-wide association study European Research Council 10.13039/501100000781 ERC-CoG-726318 British Heart Foundation 10.13039/501100000274 FS/14/49/30838 and FS/4yPhD/F/20/34127A to T.J.G British Heart Foundation 10.13039/501100000274...

... associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs). Methods and results A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons...

... for this disease. We aimed to elucidate the genetic basis of MVP in order to better understand this complex disorder. Methods and results We performed a meta-analysis of six genome-wide association studies that included 4884 cases and 434 649 controls. We identified 14 loci associated with MVP in our primary...

...://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Aims Genome-wide association studies (GWASs) have discovered...

... and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Cardiovascular genetics Genome-wide association studies Coronary artery disease Polygenic risk scores...

... cause of mortality worldwide. ³   Translational perspective With this translational research project, we report the hitherto unknown relation between tubulin-folding cofactor E (TBCE) and vascular function discovered in a genome-wide association study of 4175 individuals and further...

... genome-wide association study for atrial fibrillation . Nat Genet 2018 ; 50 : 1225 – 1233 . 3 Edwards SL , Beesley J , French JD , Dunning AM. Beyond GWASs: illuminating the dark road from association to function . Am J Hum Genet 2013 ; 93 : 779 – 797 . 4...

... by heritable susceptibility factors in the context of lifetime exposure to an atherogenic environment. Consistent with this notion, large-scale and multi-ethnic genome-wide association studies (GWAS) have identified >200 loci that influence risk of MI and CAD via perturbations of lipid metabolism, blood...

...%] identified through genome-wide association studies (GWAS) generally have individually small effect sizes but collectively have been shown to be associated with disease risk across a broad range of disease phenotypes. Intermediate effect variants (MAF < 1–5%) have effect sizes and frequencies between...

... recurrence, the observations at the latter two miRNAs confirming the recent findings of Wang et al. Besides, by conducting Genome-Wide Association Studies on miRNA levels and meta-analyzing our results with some publicly available, we identified 21 new associations of single nucleotide polymorphisms...

... the function of these discoveries and to study the role of the known risk loci in T1D. Methods and results We performed the largest genome-wide association study to date for CAD in T1D, comprising 4869 individuals with T1D (cases/controls: 941/3928). Two loci reached genome-wide significance, rs1970112...

... Sudden cardiac death Genome-wide association study Polygenic risk score Watch the interview here: youtu.be/rDwuu2YljXw 10.1093/cvr/cvz295_video1 cvz295media1 6116735765001 Highlight: In this Onlife interview, Professor Bezzina touches on her and her group’s recognition by the ESC, what...

... Republic of China. Email: [email protected] Liu Miao and Guo-Xiong Deng two authors contributed equally. 21 6 2019 21 11 2019 Two-sample Mendelian randomization (TSMR) analysis is a commonly used method with several advantages. ¹⁰ First, with the advent of genome-wide association...