... Sudden cardiac death Vascular Electron microscopy Haematoma Consecutive SCAD cases and healthy volunteers (HV) were recruited to the UK Spontaneous Coronary Artery Dissection (UKSCAD) Study (ISRCTN42661582). Patients with SCAD are recruited from across the UK by self-referral, primary care physician...

... towards the surface sarcolemma, the outermost sections of T-tubules (within ∼1μm below the surface sarcolemma) do not form a cavernous unitary space. Instead, they narrow down into a tortuous tubule of reduced diameter with local constrictions, filled with electron-dense ground substance that appears...

... and diseased cardiac tissue. Methods and results Using high-resolution electron and atomic force microscopy, we performed an exhaustive quantitative analysis of the three-dimensional (3D) structure of the CM lateral surface in different cardiac compartments from various mammalian species (mouse, rat, cow...

... evaluated by electron microscopy and compared with clinical and morphometric data. Mortality and HF recurrence were evaluated during the follow-up period. During the follow-up period (4.9 ± 3.9 years), 24 patients (10%) died and 67 (27%) were readmitted because of HF recurrence, including those who had died...

...- and inter-assay coefficients of variation were less than 8%. The assessment of CAC was performed using electron beam computed tomography (GE Imatron C-150, San Francisco, CA, USA) as previously described. ¹⁸ In brief, 40 contiguous 3 mm slices were obtained during a single breath-hold starting...

... Respirasomes Electron transport chain complexes The heart has a continuous requirement for energy in the form of ATP. Mitochondria are the primary ATP provider via the conversion of food fuels to usable energy. Compelling evidence for a link between the decline in mitochondrial energy transduction...

... (pointed) ends of the thin filaments (arrowed). The H-zone is the region in the middle of the A-band devoid of actin filaments. It is only clearly visible in electron micrographs of skeletal muscle where the thin filaments have constant lengths. Figure  2 shows snapshots of the tomograms...

... prevented by vitamin C. Conclusion: Chronic AZT administration increases blood pressure and promotes cardiovascular damage through a NAD(P)H oxidase-dependent mechanism that involves PKC δ. Vitamin C antagonizes these adverse effects of AZT in the cardiovascular system. AZT Electron microscopy ESR...

... suggest that platelet-derived SCUBE1 could function as a novel adhesive molecule and its matrix-bound and soluble fragments may play critical (patho)physiological roles in cardiovascular biology. Atherosclerosis Electron microscopy Extracellular matrix Histo(patho)logy Platelets This article...

... of an endomyocardial biopsy sample for transmission electron microscopy investigation. Between 1985 and 2004, a total of 21 patients (10 males and 11 females, mean age 24.5±14 years) retrospectively fulfilled the inclusion criteria. These patients underwent non-invasive and invasive screening at the Cardiology...

... techniques for assessing the disease process in humans. These include modalities that detect early structural changes in the coronary arteries, such as electron-beam-computed tomography, magnetic resonance imaging, and intra-vascular ultrasound; and those that detect surrogate markers for coronary...

... ischaemia. ¹⁴ Thus, the most useful surrogate definition of hibernation is viable and dysfunctional myocardium in which impaired perfusion reserve leads to inducible ischaemia. BMIPP β-methyl-iodo-pentadecanoic acid CASS Coronary Artery Surgery Study EBT electron beam X-ray computed tomography...

...-time PCR, immunohistochemistry and serial section electron microscopy were used to compare wall morphology and the distribution of gap junctions between respective vessels. Results: Expression of mRNA for Cx37, 40, 43 and 45 was similar between CPA and RFA. In the endothelium, Cx37, 40 and 43...

... enlargement and loss of matrix electron-density, without disruption of cristae architecture ( Fig. 5 ). Stereology showed a 60% increase in mitochondrial volume, coupled with a 35% decrease in the surface density of their cristae. The cristae surface per mitochondrion was unchanged ( Table 2 ), thereby...

... the prognostic value of very high coronary CSs in symptomatic males undergoing angiography and analyzed the impact of event definitions on identification of risk predictor’s. Methods and results Fifty consecutive symptomatic males with electron beam computed tomography (EBT)-based CSs >1000 were matched 1...

... is assumed to be efficiently dialysed by the low-resistance patch-pipettes used). Such a sub-sarcolemmal Na gradient was observed in separate experiments in intact rabbit papillary muscles using electron probe X-ray microanalysis. In these studies, a fuzzy-space of limited Na diffusion was observed 100–200...

...) using electron-beam CT (EBCT) [13,14] . In this study we used this technique to investigate the impact of different amounts of 10- and 100-μm polymer microspheres on porcine coronary microcirculatory function in order to enhance our understanding of the pathophysiologic consequences of embolization...

...Matthew C.P. Glyn; John G. Lawrenson; Barbara J. Ward Tissue samples were processed for electron microscopy as reported previously [4] . Three blocks from each heart were sectioned and from 4 to 7 images of capillary cross-sections were captured from two non-consecutive sections from each block...

...Sander Verheule; Emily E Wilson; Rishi Arora; Steven K Engle; Luis R Scott; Jeffrey E Olgin Electron microscopy Gap junctions Histo(patho)logy Supraventr. arrhythmia Veins * Corresponding author. Tel.: +1-317-962-0101; fax: +1-317-962-0100 [email protected] 28 1 2002 8 5 2002 Copyright...

... from plaque formation. Indirect methods are therefore unable to visualize early signs of coronary arteriosclerosis. Direct techniques are those that permit visualization of non-calcified and calcified plaque deposits within the coronary artery vessel wall. Electron beam computed tomography (EBCT...