... Clinical trials 1 2 3 4 5 News in cardiovascular pharmacotherapy from the ACC.25 Meeting 6 7 Eva Delpón, Ricardo Caballero, and Juan Tamargo* 8 ACCEPTED MANUSCRIPT 9 Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense 10 de Madrid, Instituto de Investigación Sanitaria...

... and endpoints for clinical trials involving drug-coated balloons, including defining angiographic, intravascular, and non-invasive imaging methods for lesion assessment, alongside considerations for post-revascularization pharmaco-therapy. The concept of ‘blended therapy’, which advocates for combining device...

... suboptimal adherence, defined as taking <80% of their prescribed medication within 1 year. People from poorer backgrounds and ethnic minority groups were less likely to take statins as prescribed, with differences seen between men and women. Graphical Abstract Graphical Abstract Clinical...

... by the investigators. LCA calculates the probability of each participant belonging to each latent class. ²⁸ To define these latent classes, we included the following clinical conditions: hypertension, diabetes, lipid disorders, coronary artery disease (CAD), heart failure (HF), stroke, intracranial...

... their current implementation, from prevention to treatment. Specifically, we aimed to assess their role in clinical decision-making, patient education, risk prediction, lifestyle interventions, adherence to preventive measures, and treatment recommendations. This review followed the Preferred Reporting Items...

... Clinical consensus statement Section 1: Introduction  Preamble  Scope of the document  Organization of the writing committee  Methods  Document review and approval  Brief history of epicardial access in electrophysiology Section 2: Anatomy of the pericardium  General structure...

...Antonius Büscher; Lucas Plagwitz; Kemal Yildirim; Tobias J Brix; Philipp Neuhaus; Lucas Bickmann; Amélie F Menke; Vincent F van Almsick; Hermann Pavenstädt; Philipp Kümpers; Dominik Heider; Julian Varghese; Lars Eckardt Address for correspondence: Dr. Antonius Büscher, Clinic for Cardiology II...

... strategy refers to performing ICA based on clinical assessment and/or non-invasive testing. Acute coronary syndromes STEMI, NSTE-ACS Recommendation Implementation Clinical practice guidelines Clinical practice guidelines evaluate and summarize the available evidence with the aim of assisting health...

...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Graphical Abstract Graphical Abstract Heart failure Quality registry Guideline-recommended medical therapies Clinical outcomes Swedish Heart...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract The level of evidence (LOE) grading system for European Society of Cardiology (ESC) Clinical Practice Guidelines (CPG) classifies the quality of the evidence supporting a recommendation. However, the current taxonomy does not fully consider...

... H Svendsen; Emma Svennberg; Rolf Wachter; Karl Georg Haeusler; A John Camm There is a declared need to develop a clinically applicable, unified and comprehensive concept of AF burden to improve clinical guidance, and to support research and technology development for the quantitative assessment...

...%) and before 10 years of age in 172 (60%) children. The pacing indication was prophylactic in 203 children (71%). Genetic screening was performed in 133/385 patients (34.5%), leading to the identification of a clinically actionable variant in 11 (8.3%) patients. After a median follow-up of 10 years (5–17...

... Introduction Adequate inclusion and representation of patients in clinical studies is critical for the generalizability of research findings. The aim of this analysis was to determine inclusion and reporting by age, sex, and ethnicity in clinical studies of high-risk medical devices (orthopaedic, diabetes...

...) that delete or ameliorate cellular senescence have recently emerged. Some drugs routinely used in the clinics also have anti-senescence effects. However, multiple challenges hinder the application of novel anti-senescence therapeutics in the clinical setting. Understanding the biology of cellular senescence...

.... Methods and results Randomized clinical trials (RCTs) cited in North American and European dyslipidaemia guidelines justifying primary prevention statins for cardiovascular risk reduction were critically reappraised according to eligibility criteria and characteristics of actual enrollees. Statin...

... Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background and Aims In randomized clinical trials of patients undergoing percutaneous coronary intervention (PCI) for de novo small-vessel coronary artery disease (SV-CAD), paclitaxel-coated balloon (PCB...

... of obstructive coronary artery disease (CAD) on invasive coronary angiography exist. However, as stable patients with new-onset chest pain frequently have lower clinical likelihood and preferably undergo index testing by non-invasive tests such as coronary computed tomography angiography (CCTA), clinical...

... The MyoMobile study was a single-centre, randomized, controlled three-armed parallel group clinical trial with prospective data collection to investigate the effect of a personalized mobile app health intervention compared with usual care on PA levels in patients with HFpEF. Major inclusion criteria were age...

...' involvement in clinical research within the context of cardiovascular care. The existing gaps, barriers and enablers to NAPs involvement in research as a potential response to workforce issues in these professions as well as to contribute to excellence in patient care delivery and associated outcomes...

...), and clinical outcomes in dilated cardiomyopathy (DCM) patients. Methods and results Non-ischaemic DCM patients were prospectively enrolled. Regional adipose tissue, cardiac function, and myocardial tissue characteristics were measured by cardiac magnetic resonance. The primary endpoint included all-cause...