... matrices (PWMs) from the JASPAR database as reference. ^{22 , 23} Additional methods are described in the Supplementary data . Gene regulation Transcription factor Ion channel Cardiomyopathy Ventricular arrhythmia ECG The Independent Research Fund Denmark 10.13039/501100011958 0134...

... the recommendations of the Guidelines. We address the sodium channel blocker provocation test for patients suspected of Brugada syndrome as well as the use of epinephrine, isoproterenol, adenosine, ergonovine, and acetylcholine. drug challenge provocation testing sodium channel blocker test ajmaline flecainide...

... injection. Tests to determine the cause of ICOS did not identify FMD or any other disease. The angina attacks alleviated after calcium channel blocker (CCB) administration without intervention for bilateral ICOS for 24 years since the first presentation. Moreover, coronary computed tomography angiography...

...Xiang Chen; Yan Xia; Erica Dall'Armellina; Nishant Ravikumar; Alejandro F Frangi CVD diagnosis CVD prediction cardiac biomarker multi-channel VAE mesh reconstruction UKBB Royal Academy of Engineering 10.13039/501100000287 Engineering and Physical Sciences Research Council...

... Abstract SCB, sodium channel blocker; ERC, early rhythm control; HF, heart failure; CAD, coronary artery disease; MI, myocardial infarction; CABG, coronary artery bypass graft; PCI, percutaneous coronary intervention; LVH, left ventricular hypertrophy; SR, sinus rhythm. Atrial fibrillation Early rhythm...

... projection. Subsequently, 10 mL of radio-opaque contrast (Visipaque; 1:1 dilution) was hand-injected into the irrigation port of the delivery catheter. Fluoroscopic analysis was performed in real time and fluoroscopy duration was adjusted depending on visualization of any septal venous channel or distal...

.../501100006095 Vestre Viken Hospital Trust Atrial fibrillation Rate control Beta-blockers Calcium channel blockers Natriuretic peptides Rhythm-related symptoms Graphical Abstract Graphical Abstract Figure developed by the authors with venngage.com with licence to use, reproduce and distribute...

... is the most commonly prescribed calcium channel blocker (CCB), used in the treatment of a variety of cardiovascular conditions. Calcium channel blockers remain a well-established cause of cardiovascular drug overdose. We present the case of an intentional overdose with 250 mg of amlodipine resulting in acute...

... on our site—for further information please contact [email protected]. Abstract Aims The microtubule (MT) network plays a major role in the transport of the cardiac sodium channel Na_v1.5 to the membrane, where the latter associates with interacting proteins such as dystrophin...

.../pages/standard-publication-reuse-rights ) Abstract Beta-blocker and calcium-channel blocker overdoses are associated with severe morbidity and mortality; therefore, it is important to recognize and appropriately treat individuals with toxicity. The most common clinical findings in toxicity...

... success. ^{1 , 2} However, the antegrade wiring technique must be used when there are no interventional collateral channels, according to the global CTO crossing algorithm. ³ Furthermore, compared with the antegrade approach, the retrograde approach has been recently reported...

... Bruegmann; Ingo Kutschka; Katrin Streckfuss-Bömeke; George Kensah; Lukas Cyganek; Wolfram H Zimmermann; Niels Voigt Graphical Abstract Graphical Abstract Stem cells Ion channel Action potential Atrial fibrillation Optogenetics Corresponding author. Tel: +00495513965174; fax: +00495513965169, E-mail...

... of diseases. Notably, the location of the mutation site generally has a great influence over protein function. RYR gene encodes a very large tetrameric structure protein (>2-MDa), which is also known as the largest ion channel. Wherefore, more researchers are devoted to understanding...

... interventions (i.e. shocks or antitachycardia pacing delivered for ventricular tachycardia/fibrillation). ECG, electrocardiogram; RVOT, right ventricular outflow tract; SCBT, sodium channel blocker test. Abstract The diagnosis of Brugada syndrome (BrS) requires the presence of a coved (Type 1) ST segment...

.... In young people, primary electrical diseases (‘ion channel diseases’) and cardiomyopathies (particularly hypertrophic and arrhythmogenic), both genetically determined and therefore potentially recurred in the proband’s family, as well as myocarditis and coronary anomalies prevail; in adult–elderly...

... significantly decreased protein and mRNA levels of Kv7.2 and Kv7.3 channels in the CeA of BHRs. M-currents in CeA-CRH neurons were significantly decreased in CUS-treated BHRs compared with unstressed BHRs. Blocking Kv7 channel with its blocker XE-991 increased the excitability of CeA-CRH neurons in unstressed...

...Gerard A Marchal; Niels Galjart; Vincent Portero; Carol Ann Remme Graphical Abstract Graphical Abstract Cardiac sodium channel Regulation Subcellular Microtubules Plus-end tracking proteins Fondation Leducq 10.13039/501100001674 17CVD02 Netherlands CardioVascular Research Initiative...

... Abstract Ventricular tachycardia cardiac magnetic resonance scar heterogeneous tissue channel conducting channel Abstract Aims Heterogeneous tissue channels (HTCs) detected by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) are related to ventricular arrhythmias, but there are few...

...Molly O’Reilly; Laura C Sommerfeld; C O’Shea; S Broadway-Stringer; S Andaleeb; J S Reyat; S N Kabir; D Stastny; A Malinova; D Delbue; L Fortmueller; K Gehmlich; D Pavlovic; B V Skryabin; A P Holmes; P Kirchhof; L Fabritz Sodium channel Channelopathy Atrial electrophysiology Sodium channel...

... One case, which was reported to have a rare variant in an exome cohort, had an incomplete intraventricular conduction disturbance and enlarged aortic roof, but VF never occurred. ⁴ The other case, which was in a report on the role of the HCN4 channel in preventing ventricular...