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Research Article
Thyroid Axis Adaptations to Moderate Short-term Energy Restriction in Healthy, Young Women
Skand Shekhar and others
Objective Short-term dieting has gained popularity in women. We studied thyroid hormone change after short-term, moderate energy restriction. Methods Nineteen, healthy women aged 23.36 ± 2.08 yr (mean ± SD) without obesity and thyroidal disease underwent a neutral (NEA, ±0%) and a deficient (DEA, ...
Letter
Letter to the editor: sociodemographic, lifestyle, and medical factors associated with calculated free testosterone concentrations in men: individual participant data meta-analyses
Judith A P Bons and others
Dear Editor Narinx et al. 1 study sociodemographic, lifestyle, and medical factors associated with variations in calculated free testosterone concentrations in men. 1 Their main conclusion is that calculated free testosterone concentrations are most prominently associated with age and BMI. ...
Letter
Differential cardiovascular risks of menopausal hormone therapy: insights from a Korean cohort
Qingbo Li and others
We read with great interest the article by Yuk et al ., which provides valuable insights into the association between menopausal hormone therapy (MHT) and cardiovascular disease (CVD) risk in Korean women. 1 This large-scale, population-based cohort study offers critical data on the ...
Research Article
Hyperandrogenaemia, PCOS, and Physical Fitness in Women – A Northern Finland Birth Cohort Study
Katri Tuorila and others
Objective To investigate the independent associations of hyperandrogenaemia (HA) and polycystic ovary syndrome (PCOS) with physical fitness in women among the general population. Design A population-based birth cohort study including 5889 women. Methods Longitudinal associations of serum ...
Research Article
High-intensity interval training improves insulin sensitivity in individuals with prediabetes
Pernille Mensberg and others
Objective To examine the separate and combined effects of low-volume high-intensity interval training (HIIT) and walking compared with no training on insulin sensitivity and skeletal metabolic capacity in individuals with prediabetes. Design Individuals were randomized to: (1) control (no ...
Research Article
Resolution of Paradoxical Bilateral Aldosterone Suppression with Mass Spectrometry
Taweesak Wannachalee and others
Objectives Adrenal vein sampling (AVS) is the standard-of-care for primary aldosteronism (PA) subtyping. Paradoxical bilateral aldosterone suppression (BAS), defined by lower aldosterone/cortisol ratio in both adrenal veins compared to peripheral circulation, has been reported in AVS studies, but ...
Research Article
Overweight/Obesity and Gastrointestinal Disease Incidence in Denmark—A Cohort Study
Sigrid Bjerge Gribsholt and others
Objective Obesity is associated with various gastrointestinal (GI) conditions. Because of the epidemic rise of obesity, we examined associations between overweight/obesity and incidence of individual GI diseases. Design Cohort study Methods Using nationwide healthcare registries, we identified all ...
Research Article
Neurophysin I: A Reliable, Novel, and Robust Biomarker for Oxytocin
Cihan Atila and others
Introduction Oxytocin (OXT) deficiency is a recently identified novel psycho-neuroendocrine entity associated with anxiety and reduced prosocial behavior. However, diagnosis and clinical progress have been hindered by challenges in reliably measuring OXT. Neurophysin I (NP-I), an equimolarly ...
Research Article
Deleterious variants in intolerant genes reveal new candidates for self-limited delayed puberty
Raíssa C Rezende and others
Objective Self-limited delayed puberty (SLDP) is the most common cause of delayed puberty and exhibits high heritability, although few causal genes have been identified. This study aims to identify potential candidate genes associated with SLDP. Methods Whole-exome sequencing was conducted in 71 ...
Review Article
Should Anti-Müllerian Hormone Be a Diagnosis Criterion for Polycystic Ovary Syndrome? An In-Depth Review of Pros and Cons
Emídio Vale-Fernandes and others
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology (PCOM). Despite the widespread use of the Rotterdam criteria, challenges in diagnostic accuracy persist. Anti-Müllerian hormone (AMH), a ...
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