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Fritz Bundgård-Jørgensen, Christian Hamburger, J J Pindborg, On the Effects of Cortisone and Cold Stress on the Region Around the Cut-Off Lower Incisors and the Molar Region of the White Rat, Acta Endocrinologica, Volume 28, Issue 3, Jul 1958, Pages 384–388, https://doi.org/10.1530/acta.0.0280384
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Abstract
In 1953 Selye showed that female rats with the tips of their lower incisors clipped developed an extensive and progressive gangrenous stomatitis, when treated with cortisone acetate. A 'noma'-like condition developed in the tissues around their shortened lower incisors, caused by the pathogenic situation present in these animals; i. e., damage + cortisone-induced inhibition of local defence reactions.
The purpose of the present investigation was 1) to repeat Selye's 'noma'-experiments with cortisone-treated rats using males as well as females, 2) to examine whether similar changes might occur in rats with their lower incisors clipped, not treated with cortisone, but kept for a rather long period of time under stress-provoking conditions likely to result in an increased endogenous production of adrenocortical hormones, and 3) to find out if histological examinations of the periodontal tissues would confirm the results published in the course of the last few years concerning the effects of
