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Abstract

One of the authors (Bassøe, 1956) has previously described insulin resistance, as determined by the insulin tolerance test (ITT) in 2 patients with Turner's syndrome and increased gonadotrophin excretion. One of these patients had a brother with Klinefelter's syndrome who also showed a similar response to ITT. In this patient, however, there was no increase in the excretion of gonadotrophins. Burt et al. (1954) reported that Klinefelter's syndrome and hyperplasia of the adrenals were frequently seen together. Lundstrom (1956) in his study of 5 patients with Turner's syndrome found one case with insulin resistance.

In rats ovariectomy is followed by a 500 % increase in the gonadotrophin concentration of the pituitary (Paesi et al., 1955). Furthermore, it has been shown that following castration, at least in the rat, there is an increase in the basophile elements of the pituitary gland (Gushing, 1932). It is possible that the gonadal dysgenesis in young

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