Abstract

Earlier observations showed that certain corticoids can produce favorable conditions for the development of nephrocalcinosis in rats that are simultaneously treated with an excess of phosphates (Selye & Bois, 1956). This typical instance of »conditioning« by hormones for the potential pathogenic effect of an otherwise innocuous agent has been the subject of systematic investigations in our Institute. In the course of these studies, it was accidentally discovered that, in rats treated with 2α-methyl-9α-chlorocortisol (Me-Cl-COL), the concurrent oral administration of NaH2PO4 produces acute cardiac death due to the development of massive, infarct-like myocardial necroses (Selye & Renaud, 1957). Further studies revealed that this »phosphate-steroid-cardiopathy« can in turn be inhibited by various electrolyte solutions, in particular by magnesium or potassium salts (Selye & Mishra, 1958).

The question then arose whether this striking antagonism between phosphate on the one hand, and magnesium or potassium salts on the other is due

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