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Ilja Dubinski, Susanne Bechtold-Dalla Pozza, Belana Debor, Hannah Franziska Nowotny, Nicole Reisch, Lea Tschaidse, Heinrich Schmidt, Continuous glucose monitoring in children and adolescents with congenital adrenal hyperplasia, European Journal of Endocrinology, Volume 190, Issue 5, May 2024, Pages L5–L6, https://doi.org/10.1093/ejendo/lvae036
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Dear Editor,
Continuous glucose monitoring (CGM) in tissue is an established method of therapy monitoring for type 1 diabetes mellitus in children and adolescents. For example, the rate of hypoglycaemia and ketoacidosis could be reduced.1 The range of indications for CGM expanded increasingly.2 The advantages in terms of the one-time installation of the sensor (compared to repeated capillary measurements) and the examination under domestic conditions are obvious. However, this required reference values from non-diabetic children and adolescents.3 Examples of the use of CGM in non-diabetic children include monitoring of nutrition in central nervous system impairment, real-time CGM in preterm infants, and paediatric intensive care medicine.4-6
However, the regulation of glucose homeostasis is a complex mechanism in which glucocorticoids are involved.7 It therefore seems only consequent to investigate the tissue glucose profiles in diseases with a pathophysiological deficiency of steroids (risk of hypoglycaemia) and steroid treatment (risk of hyperglycaemia). Congenital adrenal hyperplasia (CAH) is a prime example of congenital adrenal insufficiency.8