-
Views
-
Cite
Cite
Christian von Loeffelholz, Matthias Möhlig, Ayman M Arafat, Frank Isken, Joachim Spranger, Knut Mai, Harpal S Randeva, Andreas F H Pfeiffer, Martin O Weickert, Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans, European Journal of Endocrinology, Volume 162, Issue 3, Mar 2010, Pages 507–513, https://doi.org/10.1530/EJE-09-0737
Close - Share Icon Share
Abstract
To study the association of vaspin with glucose metabolism.
Cross-sectional and intervention study.
The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers. Euglycemic–hyperinsulinemic clamps (EHC) were performed in 83 of the participants. Changes of circulating vaspin levels were additionally studied in a crossover study using 300 min EHC with lipid versus saline infusion (n=10).
Neither glucose tolerance status nor insulin sensitivity, both as measured using EHCs and using homeostasis model assessment for insulin resistance (HOMA-IR), was significantly associated with serum vaspin in the cross-sectional study. Furthermore, there was no effect of short-term lipid-induced insulin resistance due to a 300 min intravenous lipid challenge on circulating vaspin. However, circulating vaspin levels were significantly elevated in women using oral contraceptives (OC), both compared to women without OC intake (1.17±0.26 vs 0.52±0.09 ng/ml, P=0.02) and males (1.17±0.26 vs 0.29±0.04 ng/ml, P=0.01). After exclusion of OC using females and stratification according to body mass index (BMI), a significant sexual dimorphism in subjects with a BMI <25 kg/m2 was observed (males 0.21±0.04 ng/ml versus females 0.70±0.16 ng/ml, P=0.009).
Our results support the existence of a sexual dimorphism regarding circulating vaspin. The lack of an association of serum vaspin with HOMA-IR and M value indicates, however, no major role for vaspin concerning insulin sensitivity in nondiabetic humans.
